2e8m: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8== | ==Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8== | ||
<StructureSection load='2e8m' size='340' side='right' caption='[[2e8m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2e8m' size='340' side='right'caption='[[2e8m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e8m]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2e8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8M FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPS8 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPS8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8m OCA], [https://pdbe.org/2e8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8m RCSB], [https://www.ebi.ac.uk/pdbsum/2e8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8m ProSAT], [https://www.topsan.org/Proteins/RSGI/2e8m TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/EPS8_HUMAN EPS8_HUMAN]] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 22: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Goroncy, A K]] | [[Category: Goroncy, A K]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
Revision as of 14:53, 10 February 2021
Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8
Structural highlights
Function[EPS8_HUMAN] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
| ||||||||||||||||