CTLA-4: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='1i8l' size='340' side='right' caption='CTLA4 | <StructureSection load='1i8l' size='340' side='right' caption='Human glycosylated CTLA4 extracellular domain (pink) complex with CD80 (grey) (PDB code [[1i8l)]]' scene=''> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28 | The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28. The complex between CTLA-4 and CD80 is formed mostly by hydrophobic contacts<ref>PMID:11279502</ref>. | ||
==3D structures of CTLA-4== | ==3D structures of CTLA-4== | ||