CTLA-4: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='1stp' size='340' side='right' caption='CTLA4 Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='CTLA4 Caption for this structure' scene=''> | ||
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The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28, | The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. The intracellular domain is similar to that of CD28, | ||
==3D structures of CTLA-4== | ==3D structures of CTLA-4== | ||