Deoxyhypusine synthase: Difference between revisions

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 == Function ==
-'''Deoxyhypusine synthase''' (DHS) plays an important role in promoting cell migration by regulating Rac-1-mediated epithelial polarity and formation of adherens junctions through Rac guanine nucleotide exchange factors<ref>PMID:22467863</ref>.  Rdx is part of the ERM (Ezrin/Radixin/Moesin) which is linked to cell shape change.  Phosphorylation of the C-terminal Thr residues of ERM inhibits cell adhesion and induces formation of spherical cell shape<ref>PMID:26555866</ref>.
+'''Deoxyhypusine synthase''' (DHS) catalyzes the biosynthesis of deoxyhypusine by transfer of 4-aminobutyl moiety of spermidine to a specific Lys residue of initiation factor 4D<ref>PMID:2108161</ref>.  Hypusine is formed post-translationally and is found in translation initiation factor 5A (elf5A).
 == Disease ==
-Rdx deficiency causes increase in bilirubin in serum, a phenotype similar to that of Dubin-Johnson syndrome in human<ref>PMID:12068294</ref>.
+Mutations in DHS result in reduced enzyme activity that limits the hypusination of elf5A which is associated with neurodevelopmental disorder<ref>PMID:30661771</ref>.
+==Relevance ==
+Inhibition of DHS may provide a strategy for reducing diabetogenic cells and preserving β cell function in type 1 diabetes<ref>PMID:24196968</ref>.
 == Structural highlights ==