Rabphilin: Difference between revisions

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 == Function ==
-'''Rabphilin''' or '''berberine bridge-forming enzyme''' (RO) is part of the alkaloids biosynthesis pathway catalyzing the conversion of (S)-reticuline to (S)-scoulerine<ref>PMID:1946465</ref>.  RO catalyzes the cyclization of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon, C-8 of (S)- <ref>PMID:7592663</ref>.
+'''Rabphilin''' (Rab) is known as a synaptic vesicle-associated protein involved in the regulation of exo- and endocytosis processes at presynaptic sites<ref>PMID:26679993</ref>.
 == Relevance ==
-Reticuline is a precursor of morphine and has potent central nervous system depressing effects<ref>PMID:9720612</ref>.
+Rab is a major auto antigen in lymphocytic infundibulo-neurohypophysitis (LINH). Antibodies to Rab may serve as a biomarker for the diagnosis of LINH<ref>PMID:25919460</ref>.
 == Structural highlights ==