SARS-CoV-2 spike protein mutations: Difference between revisions
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In January, 2021, a lineage with mutation '''L452R''' was reported to be expanding rapidly in Northern California, USA<ref name="santaclara">[https://www.sccgov.org/sites/covid19/Pages/press-release-01-17-2021-COVID-19-variant-more-frequent-in-CA.aspx COVID-19 Variant First Found in Other Countries and States Now Seen More Frequently in California], January 17, 2021, Santa Clara County Public Health, California, USA.</ref>. From late 2020 into early 2021, this lineage expanded from 4% of samples to 25%<ref name="deadline">[https://deadline.com/2021/01/another-new-covid-19-variant-in-l-a-vaccine-resistant-denmark-1234675834/ Another New Covid-19 Variant Discovered In L.A. Might Be Vaccine Resistant, Researcher Says; Strain First Identified In Denmark] by Tom Tapp in ''Deadline'', January 18, 2021.</ref>. | In January, 2021, a lineage with mutation '''L452R''' was reported to be expanding rapidly in Northern California, USA<ref name="santaclara">[https://www.sccgov.org/sites/covid19/Pages/press-release-01-17-2021-COVID-19-variant-more-frequent-in-CA.aspx COVID-19 Variant First Found in Other Countries and States Now Seen More Frequently in California], January 17, 2021, Santa Clara County Public Health, California, USA.</ref>. From late 2020 into early 2021, this lineage expanded from 4% of samples to 25%<ref name="deadline">[https://deadline.com/2021/01/another-new-covid-19-variant-in-l-a-vaccine-resistant-denmark-1234675834/ Another New Covid-19 Variant Discovered In L.A. Might Be Vaccine Resistant, Researcher Says; Strain First Identified In Denmark] by Tom Tapp in ''Deadline'', January 18, 2021.</ref>. | ||
Also in January, 2021, the lineage '''P.1''' was found to have increased rapidly in Manaus, Brazil<ref name="P1.1">[https://www.the-scientist.com/news-opinion/a-guide-to-emerging-sars-cov-2-variants-68387 A Guide to Emerging SARS-CoV-2 Variants] by Katarina Zimmer, ''The Scientist'', January 26, 2021.</ref>. P.1 has 10 mutations in the spike protein, including 3 in common with the South African lineage 501.V2 (N501Y, K417N, and E484K)<ref name="P1.1" />. | Also in January, 2021, the lineage '''P.1''' was found to have increased rapidly in Manaus, Brazil<ref name="P1.1">[https://www.the-scientist.com/news-opinion/a-guide-to-emerging-sars-cov-2-variants-68387 A Guide to Emerging SARS-CoV-2 Variants] by Katarina Zimmer, ''The Scientist'', January 26, 2021.</ref><ref name="manaus1" />. P.1 has 10 mutations in the spike protein, including 3 in common with the South African lineage 501.V2 (N501Y, K417N, and E484K)<ref name="manaus1">[https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586 Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings], Nuno R. Faria ''et al.'' on behalf of the CADDE Genomic Networ,, January 12, 2021.</ref>. P.1 was found in the USA in January, 2021<ref name="P1.1" />. | ||
===Mutations Most Concerning=== | ===Mutations Most Concerning=== | ||