Anterior gradient protein: Difference between revisions
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== Disease == | == Disease == | ||
</StructureSection> | </StructureSection> | ||
Different links between this protein and the appearance of some pathologies have been highlighted. Specially concerning diseases such as cancers or inflammatory diseases. | |||
In fact, as AGR2 proteins are involved in many biological pathways such as proteostasis or cell signaling for example, it has been possible to deduce that its involvement in proteostasis may play an important role in the development of tumors and more specifically in the multiplication of abnormal or mutated proteins in tumor cells. | |||
This protein plays a role in hormone-dependent cancers such as breast and prostate cancer. Indeed, AGR2 is not constitutive and its expression is regulated by signals. In this regard, it has been proven that when ARG2 expression is detected in women with breast cancer, their prognosis is poor. | |||
Furthermore, in a study on inflammatory diseases, it was found that a mutation on (<scene name='87/872187/Agr2_c81/2'>C81</scene>) in AGR2 causes an alteration in the interactions with mucin proteins (transmembrane protein, component of the mucus covering certain epithelial cells). | |||
In this pathway, the overexpression of AGR2 can cause an overexpression of mucus which, in breast cancer, participates in the proliferation of cancer cells and metastasis. | |||
The AGR2 protein can form complexes with Reptin which is recognized as an anti-oncogene. However, it binds more easily when the protein is in dimeric form. Thus, a mutation on (<scene name='87/872187/Agr2_e60/2'>E60</scene>) site, giving the protein a monomeric form, would reduce cancer repression by Reptin. | |||
Finally, it has also been studied that the expression of AGR2 in breast cancer patients confers chemoresistance to cancer cell growth inhibitors such as Tamoxifen. However, the mechanism involved is not very clear yet. | |||
== References == | == References == | ||
<references/> | <references/> | ||