Anterior gradient protein: Difference between revisions
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<StructureSection load='2LNS' size='350' side='right' caption='residues 41-175 of AGR2 in dimer form (PDB entry [[2lns]])' scene='87/872187/Agr2_full/1'> | <StructureSection load='2LNS' size='350' side='right' caption='residues 41-175 of AGR2 in dimer form (PDB entry [[2lns]])' scene='87/872187/Agr2_full/1'> | ||
[https://www.uniprot.org/uniprot/AGR2_HUMAN AGR2_HUMAN] | [https://www.uniprot.org/uniprot/AGR2_HUMAN AGR2_HUMAN] | ||
Originally discovered in Xenopus laevis as a cement gland differentiation regulator <ref>PMID: 31644305</ref>, <scene name='87/872187/Agr2_full/1'>Anterior Gradient Protein</scene> (AGR2) in humans is a protein chaperone involved in proteostasis, mainly for proteins expressed in epithelial cells, such as in the esophagus or lungs<ref>PMID:33005802</ref>. AGR2, composed of 175 amino acids, belongs to the protein disulfide isomerase family ([https://www.uniprot.org/uniprot/P07237 PDI]). | Originally discovered in Xenopus laevis as a cement gland differentiation regulator <ref>PMID: 31644305</ref>, <scene name='87/872187/Agr2_full/1'>Anterior Gradient Protein 2</scene> (AGR2) in humans is a protein chaperone involved in proteostasis, mainly for proteins expressed in epithelial cells, such as in the esophagus or lungs<ref>PMID:33005802</ref>. AGR2, composed of 175 amino acids, belongs to the protein disulfide isomerase family ([https://www.uniprot.org/uniprot/P07237 PDI]). | ||
== Structural highlights == | == Structural highlights == | ||
This protein contains various remarkable domains which can be visualized in the figure. | This protein contains various remarkable domains which can be visualized in the figure. | ||