Anterior gradient protein: Difference between revisions
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
== Structural highlights == | == Structural highlights == | ||
This protein contains various remarkable domains which can be visualized in the figure. | This protein contains various remarkable domains which can be visualized in the figure. | ||
'''- an unfolded NH2 terminal sequence with a peptide signal from the first to the 21st amino acid''' | '''- an unfolded NH2 terminal sequence with a peptide signal from the first to the 21st amino acid.''' | ||
'''- an active pseudo-thioredoxin domain (CXXS) from the <scene name='87/872187/Agr2_cxxs/2'>81st to the 84th amino acid</scene>. | '''- an active pseudo-thioredoxin domain (CXXS) from the <scene name='87/872187/Agr2_cxxs/2'>81st to the 84th amino acid</scene>. | ||
Called “pseudo” because there is only one active cysteine residue (<scene name='87/872187/Agr2_c81/2'>C81</scene>) | Called “pseudo” because there is only one active cysteine residue (<scene name='87/872187/Agr2_c81/2'>C81</scene>) | ||
''' - a terminal COOH sequence with a KTEL motif from the <scene name='87/872187/Agr2_cter/1'>172nd to the last</scene>''''' | ''' - a terminal COOH sequence with a KTEL motif from the <scene name='87/872187/Agr2_cter/1'>172nd to the last amino acid.</scene>''''' | ||
Moreover, this protein can be found as a monomer or a dimer, thanks to a specific motif which is EALYK between the <scene name='87/872187/Agr2_dim/1'>60th and the 64th amino acids</scene>. There are intermolecular salt bridges involving E60 and K64, in order to fix the second monomer. The CXXS domain is on the opposite side to avoid any disulfide exchange. Nevertheless, the dimeric structure is oxidation-dependent which means that C81 is necessary. | Moreover, this protein can be found as a monomer or a dimer, thanks to a specific motif which is EALYK between the <scene name='87/872187/Agr2_dim/1'>60th and the 64th amino acids</scene>. There are intermolecular salt bridges involving E60 and K64, in order to fix the second monomer. The CXXS domain is on the opposite side to avoid any disulfide exchange. Nevertheless, the dimeric structure is oxidation-dependent which means that C81 is necessary. | ||