1dd5: Difference between revisions

Revision as of 13:42, 2 May 2008

CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA RIBOSOME RECYCLING FACTOR, RRF

OverviewOverview

Ribosome recycling factor (RRF), together with elongation factor G (EF-G), catalyzes recycling of ribosomes after one round of protein synthesis. The crystal structure of RRF was determined at 2.55 angstrom resolution. The protein has an unusual fold where domain I is a long three-helix bundle and domain II is a three-layer beta/alpha/beta sandwich. The molecule superimposes almost perfectly with a transfer RNA (tRNA) except that the amino acid-binding 3' end is missing. The mimicry suggests that RRF interacts with the posttermination ribosomal complex in a similar manner to a tRNA, leading to disassembly of the complex. The structural arrangement of this mimicry is entirely different from that of other cases of less pronounced mimicry of tRNA so far described.

About this StructureAbout this Structure

1DD5 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA mimic., Selmer M, Al-Karadaghi S, Hirokawa G, Kaji A, Liljas A, Science. 1999 Dec 17;286(5448):2349-52. PMID:10600747 Page seeded by OCA on Fri May 2 13:42:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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+[[Category: Three-helix bundle]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:42:52 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:39:16 2008''