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==Virus-like particle of Beihai levi-like virus 32== | ==Virus-like particle of Beihai levi-like virus 32== | ||
<StructureSection load='6yfg' size='340' side='right'caption='[[6yfg]]' scene=''> | <StructureSection load='6yfg' size='340' side='right'caption='[[6yfg]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YFG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YFG FirstGlance]. <br> | <table><tr><td colspan='2'>[[6yfg]] is a 360 chain structure with sequence from [http://en.wikipedia.org/wiki/Beihai_levi-like_virus_32 Beihai levi-like virus 32]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YFG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YFG FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yfg OCA], [http://pdbe.org/6yfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yfg RCSB], [http://www.ebi.ac.uk/pdbsum/6yfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yfg ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6yf7|6yf7]], [[6yf9|6yf9]], [[6yfa|6yfa]], [[6yfb|6yfb]], [[6yfc|6yfc]], [[6yfd|6yfd]], [[6yfe|6yfe]], [[6yff|6yff]], [[6yfh|6yfh]], [[6yfi|6yfi]], [[6yfj|6yfj]], [[6yfk|6yfk]], [[6yfl|6yfl]], [[6yfm|6yfm]], [[6yfn|6yfn]], [[6yfo|6yfo]], [[6yfp|6yfp]], [[6yfq|6yfq]], [[6yfr|6yfr]], [[6yfs|6yfs]], [[6yft|6yft]], [[6yfu|6yfu]]</div></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yfg OCA], [http://pdbe.org/6yfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yfg RCSB], [http://www.ebi.ac.uk/pdbsum/6yfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yfg ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins (CPs) in these genomes are particularly diverse, with notable variation in length and often no recognizable similarity to previously known viruses. We recombinantly expressed metagenome-derived ssRNA phage CPs to produce virus-like particles and determined the three-dimensional structure of 22 previously uncharacterized ssRNA phage capsids covering nine distinct CP types. The structures revealed substantial deviations from the previously known ssRNA phage CP fold, uncovered an unusual prolate particle shape, and revealed a previously unseen dsRNA binding mode. These data expand our knowledge of the evolution of viral structural proteins and are of relevance for applications such as ssRNA phage-based vaccine design. | |||
Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes.,Rumnieks J, Lieknina I, Kalnins G, Sisovs M, Akopjana I, Bogans J, Tars K Sci Adv. 2020 Sep 2;6(36). pii: 6/36/eabc0023. doi: 10.1126/sciadv.abc0023. Print, 2020 Sep. PMID:32917600<ref>PMID:32917600</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6yfg" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Beihai levi-like virus 32]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kalnins G]] | [[Category: Kalnins, G]] | ||
[[Category: Lieknina I]] | [[Category: Lieknina, I]] | ||
[[Category: Rumnieks J]] | [[Category: Rumnieks, J]] | ||
[[Category: Sisovs M]] | [[Category: Sisovs, M]] | ||
[[Category: Tars K]] | [[Category: Tars, K]] | ||
[[Category: Structural protein]] | |||
[[Category: Virus]] | |||
[[Category: Virus like particle]] | |||
[[Category: Virus-like particle]] | |||