Gamma secretase: Difference between revisions

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 == Gamma Secretase Interaction In Alzheimer's Disease ==
-<scene name='81/812869/Matilda_scene_5/1'>Gamma-secretase (GS)</scene> is a multi-subunit protease complex which cleaves many transmembrane proteins; it is known as an intramembrane protease. γ-secretase is highly studied in its cleavage of amyloid precursor protein (APP) releasing beta-amyloid (Aβ  peptides) which further oligomerize to form neurofibrillary tangles and plaques in Alzheimer’s disease.<ref name= "mckeon">DOI: 10.1016/B978-012351830-9/50024-X</ref>
 <StructureSection load='5A63' size='340' side='right' caption='Cryo EM structure of glycosylated Gamma Secretase Complex; Nicastrin (grey), presenilin (green), γ secretase subunit APH-1A (pink), γ secretase subunit PEN-2 (yellow) (PDB code [[5a63]])' scene=''>
+<scene name='81/812869/Matilda_scene_5/1'>Gamma-secretase (GS)</scene> is a multi-subunit protease complex which cleaves many transmembrane proteins; it is known as an intramembrane protease. γ-secretase is highly studied in its cleavage of amyloid precursor protein (APP) releasing beta-amyloid (Aβ  peptides) which further oligomerize to form neurofibrillary tangles and plaques in Alzheimer’s disease.<ref name= "mckeon">DOI:10.1016/B978-012351830-9/50024-X</ref>
 == Background ==