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==Crystal structure of AmpC from E.coli with Nacubactam (OP0595)== | ==Crystal structure of AmpC from E.coli with Nacubactam (OP0595)== | ||
<StructureSection load='6t7l' size='340' side='right'caption='[[6t7l]]' scene=''> | <StructureSection load='6t7l' size='340' side='right'caption='[[6t7l]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T7L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T7L FirstGlance]. <br> | <table><tr><td colspan='2'>[[6t7l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T7L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T7L FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t7l OCA], [http://pdbe.org/6t7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t7l RCSB], [http://www.ebi.ac.uk/pdbsum/6t7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t7l ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=OP0:(2S,5R)-N-(2-AMINOETHOXY)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>OP0</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampC, ampA, b4150, JW4111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t7l OCA], [http://pdbe.org/6t7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t7l RCSB], [http://www.ebi.ac.uk/pdbsum/6t7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t7l ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Beta-lactamase]] | |||
[[Category: Ecoli]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brem J]] | [[Category: Brem, J]] | ||
[[Category: Lang | [[Category: Lang, P A]] | ||
[[Category: Leissing | [[Category: Leissing, T M]] | ||
[[Category: Schofield | [[Category: Schofield, C J]] | ||
[[Category: Antibiotic resistance]] | |||
[[Category: Beta lactamase]] | |||
[[Category: Dbo]] | |||
[[Category: Diazabicyclooctane]] | |||
[[Category: Hydrolase]] | |||
Revision as of 11:09, 2 December 2020
Crystal structure of AmpC from E.coli with Nacubactam (OP0595)Crystal structure of AmpC from E.coli with Nacubactam (OP0595)
Structural highlights
Function[AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. |
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