6ruu: Difference between revisions
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==Pseudokinase domain of human IRAK3== | ==Pseudokinase domain of human IRAK3== | ||
<StructureSection load='6ruu' size='340' side='right'caption='[[6ruu]]' scene=''> | <StructureSection load='6ruu' size='340' side='right'caption='[[6ruu]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RUU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RUU FirstGlance]. <br> | <table><tr><td colspan='2'>[[6ruu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RUU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RUU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ruu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ruu OCA], [http://pdbe.org/6ruu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ruu RCSB], [http://www.ebi.ac.uk/pdbsum/6ruu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ruu ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRAK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ruu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ruu OCA], [http://pdbe.org/6ruu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ruu RCSB], [http://www.ebi.ac.uk/pdbsum/6ruu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ruu ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cohen P]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Kulathu Y]] | [[Category: Cohen, P]] | ||
[[Category: Lange | [[Category: Kulathu, Y]] | ||
[[Category: Lange, S M]] | |||
[[Category: Homo-dimer]] | |||
[[Category: Innate immunity]] | |||
[[Category: Pseudokinase]] | |||
[[Category: Signaling protein]] | |||