Thiaminase: Difference between revisions

Revision as of 12:10, 25 November 2020

Function

Thiaminase (Thi) or thiamine pyridinylase cleaves vitamin B1. Thiaminase I catalyzes the elimination of the thiazole ring moiety from the thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound^[1]. Thiaminase II catalyzes the hydrolysis of thiamin ^[2].

Structural highlights

The . and the ^[3].

3D Structures of thiaminase3D Structures of thiaminase

Updated on 25-November-2020

ReferencesReferences

↑ Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D. Structure of a eukaryotic thiaminase I. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110., Epub 2013 Dec 18. PMID:24351929 doi:http://dx.doi.org/10.1073/pnas.1315882110
↑ Onozuka M, Konno H, Kawasaki Y, Akaji K, Nosaka K. Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae. FEMS Yeast Res. 2008 Mar;8(2):266-75. Epub 2007 Nov 19. PMID:18028398 doi:http://dx.doi.org/10.1111/j.1567-1364.2007.00333.x
↑ Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. PMID:15709744 doi:http://dx.doi.org/10.1021/bi0478648

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Kreinbring CA, Remillard SP, Hubbard P, Brodkin HR, Leeper FJ, Hawksley D, Lai EY, Fulton C, Petsko GA, Ringe D. Structure of a eukaryotic thiaminase I. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):137-42. doi: 10.1073/pnas.1315882110., Epub 2013 Dec 18. PMID:24351929 doi:http://dx.doi.org/10.1073/pnas.1315882110

[2] Onozuka M, Konno H, Kawasaki Y, Akaji K, Nosaka K. Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae. FEMS Yeast Res. 2008 Mar;8(2):266-75. Epub 2007 Nov 19. PMID:18028398 doi:http://dx.doi.org/10.1111/j.1567-1364.2007.00333.x

[3] Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. PMID:15709744 doi:http://dx.doi.org/10.1021/bi0478648

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 == Function ==
-'''Thiaminase''' (Thi) cleaves vitamin B1.  '''Thiaminase I''' catalyzes the elimination of the thiazole ring moiety from the thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound<ref>PMID:24351929</ref>.  '''Thiaminase II''' catalyzes the hydrolysis of thiamin <ref>PMID:18028398</ref>.
+'''Thiaminase''' (Thi) or '''thiamine pyridinylase''' cleaves vitamin B1.  '''Thiaminase I''' catalyzes the elimination of the thiazole ring moiety from the thiamin through substitution of the methylene group with a nitrogenous base or sulfhydryl compound<ref>PMID:24351929</ref>.  '''Thiaminase II''' catalyzes the hydrolysis of thiamin <ref>PMID:18028398</ref>.
 == Structural highlights ==