Sandbox GGC1: Difference between revisions
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There are mutations in H3.3 that are found in different types of bone tumors like [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446520/ chrondroblastoma] for example and giant cell tumors of the bone Chondroblastoma arises in children and in young adults in the cartilage of the growth plates of the long bones and is most typically benign. | There are mutations in H3.3 that are found in different types of bone tumors like [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446520/ chrondroblastoma] for example and giant cell tumors of the bone Chondroblastoma arises in children and in young adults in the cartilage of the growth plates of the long bones and is most typically benign. | ||
== Relevance == | == Relevance == | ||
Histone octamer containing two of H2A, H2B, H3 and H4 and the octamer wraps 147bp of DNA. H3.3 interacts with HIRA which is a chaperone and ZMYND11 when trimethylated at | Histone octamer containing two of H2A, H2B, H3 and H4 and the octamer wraps 147bp of DNA. H3.3 interacts with HIRA which is a chaperone and ZMYND11 when trimethylated at <scene name='75/752263/3wtp/2'>Lysine-36</scene> | ||
== Structural highlights == | == Structural highlights == | ||
in a PubMed abstract,[https://www.nature.com/articles/srep07115 CENP-A]which is a centromere-specific histone H3 variant is over expressed in cancer cells and it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. | in a PubMed abstract,[https://www.nature.com/articles/srep07115 CENP-A]which is a centromere-specific histone H3 variant is over expressed in cancer cells and it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. | ||