Glucagon-like peptide 1 receptor: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Karsten Theis

@@ Line 6: / Line 6: @@
 == Relevance ==
-GLP-1R agonists are used in treatment of type 2 diabetes<ref>PMID:21950636</ref>.  GLP-1 analogues can cross the brain-blood barrier and stimulate the GLP-1R in the brain.  This stimulation  is affecting mitochondrial functioning, protein aggregation, neuroinflammation, synaptic plasticity, learning and memory in  models of Parkinson Disease and Alzheimer Disease<ref>PMID:26851597</ref>.
+GLP-1R agonists are used in treatment of type 2 diabetes<ref>PMID:21950636</ref>. GLP-1 analogues can cross the brain-blood barrier and stimulate the GLP-1R in the brain.  This stimulation  is affecting mitochondrial functioning, protein aggregation, neuroinflammation, synaptic plasticity, learning and memory in  models of Parkinson Disease and Alzheimer Disease<ref>PMID:26851597</ref>.
 == Structural highlights ==
-The 3D structure of the complex of GLP-1R and GLP-1 shows the GLP-1 peptide as a kinked helix.  The ampiphilic GLP-1 helix shows <scene name='84/841095/Cv/2'>hydrophilic</scene> and <scene name='84/841095/Cv/3'>hydrophobic</scene> interactions with GLP-1R on opposite faces<ref>PMID:19861722</ref>.
+The 3D structure of the complex of GLP-1R and GLP-1 shows the GLP-1 peptide as a kinked helix. The ampiphilic GLP-1 helix shows <scene name='84/841095/Cv/2'>hydrophilic</scene> and <scene name='84/841095/Cv/3'>hydrophobic</scene> interactions with GLP-1R on opposite faces<ref>PMID:19861722</ref>. <scene name='84/841095/Cv/5'>GLP-1R/GLP-1 salt bridges and H-bonds</scene>.
 </StructureSection>