1cwk: Difference between revisions

Revision as of 13:11, 2 May 2008

HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN

OverviewOverview

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.

About this StructureAbout this Structure

1CWK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216 Page seeded by OCA on Fri May 2 13:11:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1cwk.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1cwk |SIZE=350|CAPTION= <scene name='initialview01'>1cwk</scene>, resolution 1.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1cwk", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=BIN:Cyclosporin+Binding+Site'>BIN</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MSA:(2-S-METHYL)+SARCOSINE'>MSA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=TMD:(6,7-DIHYDRO)4-[(E)-BUTENYL]-4,N-DIMETHYL-THREONINE'>TMD</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_1cwk|  PDB=1cwk  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwk OCA], [http://www.ebi.ac.uk/pdbsum/1cwk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cwk RCSB]</span>
-}}
 '''HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN'''
@@ Line 30: / Line 27: @@
 [[Category: Taylor, P.]]
 [[Category: Walkinshaw, M D.]]
-[[Category: complex (isomerase/immunosuppressant)]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:11:20 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:29:57 2008''