Ribosome recycling factor: Difference between revisions

Revision as of 13:02, 26 October 2020

Function

Ribosome recycling factor (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis.

RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation^[1]. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA.

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. Water molecule is shown as red sphere.

E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code 1ek8)

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3D Structures of ribosome recycling factor3D Structures of ribosome recycling factor

Updated on 26-October-2020

ReferencesReferences

↑ Hirokawa G, Nijman RM, Raj VS, Kaji H, Igarashi K, Kaji A. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA. 2005 Aug;11(8):1317-28. PMID:16043510 doi:http://dx.doi.org/10.1261/rna.2520405

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Hirokawa G, Nijman RM, Raj VS, Kaji H, Igarashi K, Kaji A. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA. 2005 Aug;11(8):1317-28. PMID:16043510 doi:http://dx.doi.org/10.1261/rna.2520405

[1]

@@ Line 15: / Line 15: @@
 *Ribosome recycling factor
+**[[1wih]] – RRF mitochondrial domain II – mouse - NMR <br />
 **[[1dd5]] – RRF – ''Thermotoga maritima'' <br />
 **[[1eh1]] – TtRRF – ''Thermus thermophilus'' <br />
@@ Line 24: / Line 25: @@
 **[[4kb2]], [[4kb4]], [[4kc6]], [[4kaw]] – MtRRF (mutant) <br />
 **[[4gfq]] – RRF – ''Bacillus anthracis'' <br />
-**[[1wih]] – RRF mitochondrial domain II – mouse - NMR <br />
+**[[6vud]] – RRF – ''Ehrlichia chafeensis''<br />
 *Ribosome recycling factor in the ribosome
-**[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF + part of 50S ribosome <br />
+**[[5mlc]] – RRF in 50S ribosome – spinach - Cryo-EM <br />
-**[[1t1m]], [[1zn1]] – EcRRF + part of 70S ribosome – Cryo-EM <br />
+**[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF in 50S ribosome <br />
-**[[1zn0]], [[2rdo]] – EcRRF + part of 50S ribosome – Cryo-EM <br />
+**[[1t1m]], [[1zn1]] – EcRRF in 70S ribosome – Cryo-EM <br />
-**[[3j0d]], [[3j0e]] – TtRRF + part of Ec50S ribosome – Cryo-EM <br />
+**[[1zn0]], [[2rdo]] – EcRRF in 50S ribosome – Cryo-EM <br />
-**[[4v5a]] – TtRRF + part of 70S ribosome  <br />
+**[[3j0d]], [[3j0e]] – TtRRF in Ec50S ribosome – Cryo-EM <br />
-**[[1y69]] – RRF + part of 50S ribosome – ''Deinococcus radiodurans'' <br />
+**[[4v5a]] – TtRRF in 70S ribosome  <br />
+**[[1y69]] – RRF in 50S ribosome – ''Deinococcus radiodurans'' <br />
 }}
 == References ==
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 [[Category:Topic Page]]