5ygm: Difference between revisions
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==Monomeric structure of concanavalin A at pH 7.5 from Carnivalia ensiformis== | ==Monomeric structure of concanavalin A at pH 7.5 from Carnivalia ensiformis== | ||
<StructureSection load='5ygm' size='340' side='right' caption='[[5ygm]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='5ygm' size='340' side='right'caption='[[5ygm]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ygm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brazilian_jack_bean Brazilian jack bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGM OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[5ygm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brazilian_jack_bean Brazilian jack bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YGM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ygm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygm OCA], [http://pdbe.org/5ygm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ygm RCSB], [http://www.ebi.ac.uk/pdbsum/5ygm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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==See Also== | ==See Also== | ||
*[[Concanavalin | *[[Concanavalin 3D structures|Concanavalin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Brazilian jack bean]] | [[Category: Brazilian jack bean]] | ||
[[Category: Large Structures]] | |||
[[Category: Lee, S J]] | [[Category: Lee, S J]] | ||
[[Category: Park, J H]] | [[Category: Park, J H]] | ||
Revision as of 12:19, 21 October 2020
Structural highlights
Function[CONA_CANEN] D-mannose specific lectin. Publication Abstract from PubMedThe structure of concanavalin A (ConA) has been studied intensively due to its specific interactions with carbohydrates and its heterometal (Ca2+ and Mn2+) coordination. Most structures from X-ray crystallography have shown ConA as a dimer or tetramer, because the complex formation requires specific crystallization conditions. Here, we reported a monomeric structure of ConA with a resolution of 1.6 A, which revealed that metal coordination could trigger sugar binding ability. The calcium coordination residue, Asn14, changes the orientation of carbohydrate binding residues and biophysical details, including structural information, providing valuable clues for the development and application of detection kits using ConA. Heterometal-coordinated monomeric concanavalin A at pH 7.5 from Canavalia ensiformis.,Chung NJ, Park YR, Lee DH, Park JH, Lee SJ J Microbiol Biotechnol. 2017 Oct 13. doi: 10.4014/jmb.1709.09057. PMID:29025256[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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