Ras-related protein Rab: Difference between revisions

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</StructureSection>
</StructureSection>
==3D structures of Ras-related protein Rab==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Rab-1 GTPase domain 1-178
**[[2fol]] – hRab-1 + GDP - human<br />
**[[6sku]] – hRab-1 + AnkX + GDP<br />
**[[5szh]], [[5szk]] – hRab-1 + Mical-cL + GNP<br />
**[[4i1o]] – hRab-1 + LepB + GDP<br />
**[[4fmb]] – hRab-1 + VirA + GDP<br />
**[[3tkl]] – hRab-1 + LidA + GTP<br />
**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br />
**[[3nkv]] – hRab-1 + GNP + AMP<br />
**[[3jza]], [[2wwx]], [[3l0i]] – hRab-1 + DrrA <br />
**[[5o74]] – hRab-1 + DrrA + GDP <br />
*Rab-2
**[[2a5j]] – hRab-2 + GDP<br />
*Rab-3
**[[2gf9]] – hRab-3 + GDP <br />
**[[3rab]] – Rab-3 + GNP - rat<br />
**[[4rkf]] – DmRab-3 + GDP - ''Drosophila melanogaster''<br />
*Rab-4
**[[2o52]] – hRab-4 + GDP<br />
**[[1yu9]] – hRab-4 + GNP<br />
*Rab-5C
**[[4kyi]] – hRab-5C + VipD + GNP<br />
**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br />
**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br />
**[[1huq]] – mRab-5C + GNP <br />
*Rab-6
**[[2e9s]], [[2fe4]], [[4dkx]] – hRab-6 + GDP <br />
**[[2ffq]] – hRab-6 + GSP <br />
**[[2gil]] – hRab-6 + GTP <br />
**[[1yzq]] – hRab-6 + GNP <br />
**[[3bbp]] – hRab-6 + GCC185 + GTP <br />
**[[3cwz]] – mRab-6 + R6IP1 + GTP <br />
**[[5lef]] – mRab-6 + KIF20A + GTP <br />
**[[2y8e]] – DmRab-5C + GNP <br />
*Rab-7L1
**[[6hh2]] – hRab-7L1 + GDP <br />
*Rab-8
**[[6sq2]] – hRab-8 + GTP<br />
**[[6stg]], [[4lhw]] – hRab-8 + GNP<br />
**[[6stf]], [[4lhv]] – hRab-8 + GDP<br />
*Rab-9
**[[1wms]] – hRab-9 + GDP<br />
**[[2ocb]] – hRab-9 + GNP<br />
**[[1s8f]] – Rab-9 + GDP - dog<br />
**[[1yzl]] – mRab-9 + GNP<br />
**[[4qxa]] – mRab-9 + RUTBC2 + GTP<br />
*Rab-11A complex with nucleotide
**[[1oiv]], [[6yi1]] – hRab-11A + GDP<br />
**[[1oix]] – hRab-11A (mutant) + GDP <br />
**[[5ez5]] – hRab-11A (mutant) + GTP <br />
**[[1yzk]] – hRab-11A + GppNHp<br />
**[[1oiw]] – hRab-11A (mutant) + GTPγS <br />
**[[3bfk]] – Rab-11A + GDP – ''Plasmodium falciparum''<br />
**[[5xr4]] – AtRab-11A + GDP – ''Arabidopsis thaliana''<br />
**[[5xr7]] – AtRab-11A (mutant) + GTP <br />
**[[5xr6]] – AtRab-11A + GppNHp<br />
*Rab-11A other complexes
**[[4c4p]] – hRab-11A + Rab11 family-interacting protein 2 <br />
**[[2gzd]], [[2gzh]] – hRab-11A (mutant) + Rab11 family-interacting protein 2 <br />
**[[2hv8]], [[2d7c]] – hRab-11A (mutant) + Rab11 family-interacting protein 3<br />
**[[4d0m]] – hRab-11A (mutant) + Rab11 family-interacting protein 3 + PI4KB<br />
**[[4uj5]] – hRab-11A (mutant) + Rab-3A interacting protein 3<br />
**[[4uj3]], [[4uj4]] – hRab-11A (mutant) + Rab11 family-interacting protein 3 + Rab-3A interacting protein 3<br />
**[[5jcz]] – hRab-11A + unconventional myosin-Va<br />
**[[4lwz]], [[4lx0]] – hRab-11A + unconventional myosin-Vb<br />
**[[4fmd]] – hRab-11A + EspG + GDP<br />
**[[6djl]] – hRab-11A (mutant) + SH3 domain-binding protein 5<br />
**[[5fbl]], [[5fbq]], [[5fbr]], [[5fbv]], [[5fbw]] – hRab-11A + PI4KB + inhibitor<br />
**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br />
**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br />
*Rab-11B
**[[2f9l]] – hRab-11B + GDP <br />
**[[2f9m]] – hRab-11B + GNP <br />
*Rab-12
**[[2il1]] – hRab-12 + GDP <br />
*Rab-14
**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br />
**[[4drz]], [[1z0f]] – hRab-14 + GDP <br />
*Rab-18
**[[1x3s]] – hRab-18 + GNP <br />
*Rab-22
**[[1yvd]] – mRab-22 + GNP <br />
**[[1z0j]] – mRab-22 (mutant) + rabenosyn-5 + GTP <br />
*Rab-23
**[[1z22]], [[1z2a]] – mRab-23 + GDP<br />
*Rab-25
**[[2oil]] – hRab-25 + GDP <br />
**[[3tso]] – hRab-25 + Rab11 family-interacting protein 2 <br />
*Rab-26
**[[2g6b]] – hRab-26 + GNP <br />
*Rab-27
**[[2f7s]] – hRab-27 + GDP <br />
**[[2iey]], [[2iez]], [[2if0]] – mRab-27 + GDP <br />
**[[2zet]] – mRab-27 + melanophilin + GDP <br />
*Rab-28
**[[2hxs]] – hRab-28 + G3D <br />
**[[3e5h]] – hRab-28 + GND <br />
*Rab-30
**[[2ew1]] – hRab-30 + GNP <br />
*Rab-31
**[[2fg5]] – hRab-31 + GNP <br />
*Rab-32
**[[6ff8]] – hRab-32 + GTP <br />
**[[5oed]], [[5oec]] – hRab-32 + GtgE + GDP <br />
*Rab-33
**[[1z06]] – mRab-33 + Gyp1 + GDP <br />
**[[2g77]] – mRab-33 + GNP <br />
**[[6zay]] – mRab-33 + Atg16L + GDP <br />
**[[6y09]], [[6sur]] – mRab-33 + Atg16L + GTP <br />
*Rab-35
**[[6if2]] – hRab-35 + GTP <br />
**[[6if3]] – hRab-35 + ACAP2 + GTP <br />
**[[6ekk]] – hRab-35 + DENDD 1A + GDP <br />
**[[3tw8]] – hRab-35 + DENDD 1B <br />
*Rab-38
**[[6s5h]], [[6hdu]] – hRab-38 + GTP <br />
*Rab-39B
**[[6s5f]] – hRab-39B + GMPPNP <br />
*Rab-43
**[[2hup]] – hRab-43 + GDP <br />
}}


== References ==
== References ==

Revision as of 11:22, 18 October 2020


Function

Ras-related protein Rab-11A belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways and with pathways regulating protein traffic. Rab cycles between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors responsible for vesicle formation, movement, tethering and fusion.

Disease

Rab-11A, Rab-11B and Rab-25 are associated with Alzheimer disease, Huntington disease, type 2 diabetes and cancer[1].

Structural highlights

Rab-11A undergoes a conformation change of between its inactive GDP-bound structure and its active GTP-bound structure. located at the surface of the protein[2]. Water molecules are shown as red spheres.

3D structures of Ras-related protein Rab


Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code 1oix)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015 Winter;4(1):1-8. PMID:25815277
  2. ↑ Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J. The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. J Biol Chem. 2004 Mar 19;279(12):11480-8. Epub 2003 Dec 29. PMID:14699104 doi:10.1074/jbc.M310558200

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Michal Harel, Alexander Berchansky
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