Ras-related protein Rab: Difference between revisions
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Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | ||
[[3D structures of Ras-related protein Rab]] | |||
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Rab-1 | *Rab-1 GTPase domain 1-178 | ||
**[[2fol]] – hRab-1 + GDP - human<br /> | **[[2fol]] – hRab-1 + GDP - human<br /> | ||
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**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br /> | **[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br /> | ||
**[[3nkv]] – hRab-1 + GNP + AMP<br /> | **[[3nkv]] – hRab-1 + GNP + AMP<br /> | ||
**[[3jza]] – hRab-1 + DrrA <br /> | **[[3jza]], [[2wwx]], [[3l0i]] – hRab-1 + DrrA <br /> | ||
**[[5o74]] – hRab-1 + DrrA + GDP <br /> | **[[5o74]] – hRab-1 + DrrA + GDP <br /> | ||
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**[[2gf9]] – hRab-3 + GDP <br /> | **[[2gf9]] – hRab-3 + GDP <br /> | ||
**[[4rkf]] – | **[[3rab]] – Rab-3 + GNP - rat<br /> | ||
**[[4rkf]] – DmRab-3 + GDP - ''Drosophila melanogaster''<br /> | |||
*Rab-4 | *Rab-4 | ||
**[[2o52]] – hRab-4 + GDP<br /> | **[[2o52]] – hRab-4 + GDP<br /> | ||
**[[1yu9]] – hRab-4 + GNP<br /> | |||
*Rab-5C | *Rab-5C | ||
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**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br /> | **[[1z02]] – mRab-5C (mutant) + GNP - mouse<br /> | ||
**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br /> | **[[1z0d]], [[1z0a]] – mRab-5C + GDP <br /> | ||
**[[1huq]] – mRab-5C + GNP <br /> | |||
*Rab-6 | *Rab-6 | ||
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**[[2ffq]] – hRab-6 + GSP <br /> | **[[2ffq]] – hRab-6 + GSP <br /> | ||
**[[2gil]] – hRab-6 + GTP <br /> | **[[2gil]] – hRab-6 + GTP <br /> | ||
**[[1yzq]] – hRab-6 + GNP <br /> | |||
**[[3bbp]] – hRab-6 + GCC185 + GTP <br /> | **[[3bbp]] – hRab-6 + GCC185 + GTP <br /> | ||
**[[3cwz]] – mRab-6 + R6IP1 + GTP <br /> | **[[3cwz]] – mRab-6 + R6IP1 + GTP <br /> | ||
**[[5lef]] – mRab-6 + KIF20A + GTP <br /> | **[[5lef]] – mRab-6 + KIF20A + GTP <br /> | ||
**[[2y8e]] – DmRab-5C + GNP <br /> | |||
*Rab-7L1 | *Rab-7L1 | ||
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**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br /> | **[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br /> | ||
**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br /> | **[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br /> | ||
*Rab-11B | |||
**[[2f9l]] – hRab-11B + GDP <br /> | |||
**[[2f9m]] – hRab-11B + GNP <br /> | |||
*Rab-12 | |||
**[[2il1]] – hRab-12 + GDP <br /> | |||
*Rab-14 | *Rab-14 | ||
**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br /> | **[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br /> | ||
**[[4drz]] – hRab-14 + GDP <br /> | **[[4drz]], [[1z0f]] – hRab-14 + GDP <br /> | ||
*Rab-18 | *Rab-18 | ||
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*Rab-33 | *Rab-33 | ||
**[[1z06]] – mRab-33 + Gyp1 | **[[1z06]] – mRab-33 + Gyp1 + GDP <br /> | ||
**[[2g77]] – mRab-33 + GNP <br /> | **[[2g77]] – mRab-33 + GNP <br /> | ||
**[[6zay]] – mRab-33 + Atg16L + GDP <br /> | **[[6zay]] – mRab-33 + Atg16L + GDP <br /> | ||
Revision as of 11:20, 18 October 2020
FunctionRas-related protein Rab-11A belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways and with pathways regulating protein traffic. Rab cycles between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors responsible for vesicle formation, movement, tethering and fusion. DiseaseRab-11A, Rab-11B and Rab-25 are associated with Alzheimer disease, Huntington disease, type 2 diabetes and cancer[1]. Structural highlightsRab-11A undergoes a conformation change of between its inactive GDP-bound structure and its active GTP-bound structure. located at the surface of the protein[2]. Water molecules are shown as red spheres. 3D structures of Ras-related protein Rab
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Updated on 18-October-2020
ReferencesReferences
- ↑ Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015 Winter;4(1):1-8. PMID:25815277
- ↑ Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J. The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. J Biol Chem. 2004 Mar 19;279(12):11480-8. Epub 2003 Dec 29. PMID:14699104 doi:10.1074/jbc.M310558200