1csm: Difference between revisions

Revision as of 13:04, 2 May 2008

THE CRYSTAL STRUCTURE OF ALLOSTERIC CHORISMATE MUTASE AT 2.2 ANGSTROMS RESOLUTION

OverviewOverview

The crystal structure of an allosteric chorismate mutase, the Thr-226-->Ile mutant, from yeast Saccharomyces cerevisiae has been determined to 2.2-A resolution by using the multiple isomorphous replacement method. Solvent-flattening and electron-density modification were applied for phase improvement. The current crystallographic R factor is 0.196. The final model includes 504 of the 512 residues and 97 water molecules. In addition, two tryptophan molecules were identified in the interface between monomers. The overall structure is completely different from the reported structure of chorismate mutase from Bacillus subtilis. This structure showed 71% helices with essentially no beta-sheet structures.

About this StructureAbout this Structure

1CSM is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of allosteric chorismate mutase at 2.2-A resolution., Xue Y, Lipscomb WN, Graf R, Schnappauf G, Braus G, Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10814-8. PMID:7971967 Page seeded by OCA on Fri May 2 13:04:21 2008

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OCA

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 [[Image:1csm.gif|left|200px]]
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-}}
 '''THE CRYSTAL STRUCTURE OF ALLOSTERIC CHORISMATE MUTASE AT 2.2 ANGSTROMS RESOLUTION'''
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 [[Category: Lipscomb, W N.]]
 [[Category: Xue, Y.]]
-[[Category: isomerase]]
+[[Category: Isomerase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:04:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:27:45 2008''