1cqe: Difference between revisions

Revision as of 13:00, 2 May 2008

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN

OverviewOverview

The three-dimensional structure of prostaglandin H2 synthase-1, an integral membrane protein, has been determined at 3.5 A resolution by X-ray crystallography. This bifunctional enzyme comprises three independent folding units: an epidermal growth factor domain, a membrane-binding motif and an enzymatic domain. Two adjacent but spatially distinct active sites were found for its haem-dependent peroxidase and cyclooxygenase activities. The cyclooxygenase active site is created by a long, hydrophobic channel that is the site of non-steroidal anti-inflammatory drug binding. The conformation of the membrane-binding motif strongly suggests that the enzyme integrates into only one leaflet of the lipid bilayer and is thus a monotopic membrane protein.

About this StructureAbout this Structure

1CQE is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

ReferenceReference

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1., Picot D, Loll PJ, Garavito RM, Nature. 1994 Jan 20;367(6460):243-9. PMID:8121489 Page seeded by OCA on Fri May 2 13:00:09 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1cqe.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1cqe |SIZE=350|CAPTION= <scene name='initialview01'>1cqe</scene>, resolution 3.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1cqe", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=COA:Hydrophobic+Channel+Responsible+For+Cycloogenase+Activity'>COA</scene>, <scene name='pdbsite=COB:Hydrophobic+Channel+Responsible+For+Cycloogenase+Activity'>COB</scene>, <scene name='pdbsite=POA:Heme+Pocket+Responsible+For+Peroxidase+Activity'>POA</scene> and <scene name='pdbsite=POB:Heme+Pocket+Responsible+For+Peroxidase+Activity'>POB</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FLP:FLURBIPROFEN'>FLP</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1cqe|  PDB=1cqe  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cqe OCA], [http://www.ebi.ac.uk/pdbsum/1cqe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cqe RCSB]</span>
-}}
 '''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN'''
@@ Line 30: / Line 27: @@
 [[Category: Mulichak, A M.]]
 [[Category: Picot, D.]]
-[[Category: dioxygenase]]
+[[Category: Dioxygenase]]
-[[Category: oxidoreductase]]
+[[Category: Oxidoreductase]]
-[[Category: peroxidase]]
+[[Category: Peroxidase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:00:09 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:26:30 2008''