5vsr: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1== | ==ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1== | ||
<StructureSection load='5vsr' size='340' side='right' caption='[[5vsr]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='5vsr' size='340' side='right'caption='[[5vsr]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5vsr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VSR OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[5vsr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VSR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VSR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF0:N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide'>AF0</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AF0:N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide'>AF0</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vr7|5vr7]], [[5vsq|5vsq]], [[5vro|5vro]], [[5vs5|5vs5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vr7|5vr7]], [[5vsq|5vsq]], [[5vro|5vro]], [[5vs5|5vs5]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vsr OCA], [http://pdbe.org/5vsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vsr RCSB], [http://www.ebi.ac.uk/pdbsum/5vsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vsr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 20: | Line 20: | ||
</div> | </div> | ||
<div class="pdbe-citations 5vsr" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5vsr" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]] | |||
*[[Protein Phosphatase 2C|Protein Phosphatase 2C]] | |||
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
[[Category: Cao, M J]] | [[Category: Cao, M J]] | ||
Revision as of 11:44, 30 September 2020
ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1
Structural highlights
Function[PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2] [P2C16_ARATH] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.[3] [4] [5] [6] Publication Abstract from PubMedDrought stress is a major threat to crop production, but effective methods to mitigate the adverse effects of drought are not available. Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (ABA) receptor agonist AM1 optimizes its binding to ABA receptors by increasing the number of hydrogen bonds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocket. The new chemicals, known as AMFs, have long-lasting effects in promoting stomatal closure and inducing the expression of stress-responsive genes. Application of AMFs or transgenic overexpression of the receptor PYL2 in Arabidopsis and soybean plants confers increased drought resistance. The greatest increase in drought resistance is achieved when AMFs are applied to the PYL2-overexpression transgenic plants. Our results demonstrate that the combining of potent chemicals with transgenic overexpression of an ABA receptor is very effective in helping plants combat drought stress. Combining chemical and genetic approaches to increase drought resistance in plants.,Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK Nat Commun. 2017 Oct 30;8(1):1183. doi: 10.1038/s41467-017-01239-3. PMID:29084945[7] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||||||