Ankyrin repeat domain-containing protein: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='5ybv' size='340' side='right' caption='Mouse ARDCP 3 complex with anti cancer drug lestaurtinib and Cl- ion (green) (PDB code [[5wnj]]).' scene=''> | ||
== Function == | == Function == | ||
Revision as of 10:55, 30 September 2020
FunctionAnkyrin repeat domain-containing protein (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain[1]. DiseaseRelevanceStructural highlights |
| ||||||||||
3D structures of ankyrin repeat domain-containing protein3D structures of ankyrin repeat domain-containing protein
4nl9 - hARDCP 3 SAM domain + hARDCP 14 SAM domain - human
5ybj - hARDCP 15 residues 1080-1329
5ybu - hARDCP 15 residues 1080-1329 + KIF21A peptide
4hbd - hARDCP 25 residues 578-832
5ybv - hARDCP 25 residues 578-832 + KIF21A peptide
4cym - hARDCP 27 residues 450-640 + RAB32
4cz2 - hARDCP 27 residues 450-640 + RAB32 + GPPCP
4b93 - hARDCP 27 residues 659-921 + VAMP7
5wni - mARDCP 3 residues 1-342 - mouse
5wnk - mARDCP 3 residues 1-342 (mutant)
5wnj, 5wnm - mARDCP 3 residues 1-342 (mutant) + cancer drug
5wnl - mARDCP 3 residues 1-342 (mutant) + staurosporine
6nxf - mARDCP 31 C-terminal + REC114
5eid, 4tum - AtARDCP 2 residues 211-342 - Arabidopis thaliana
6jd6 - AtARDCP EMB56 + ARDCP
ReferencesReferences
- ↑ Guo Q, Liao S, Zhu Z, Li Y, Li F, Xu C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J Biol Chem. 2017 Nov 28. pii: M117.817494. doi: 10.1074/jbc.M117.817494. PMID:29183992 doi:http://dx.doi.org/10.1074/jbc.M117.817494