1cma: Difference between revisions

Revision as of 12:53, 2 May 2008

Ligands:

Structural annotation:
Resources:	CATH : 1Cmaa00, 1Cmab00 InterPro : Ipr010985, Ipr002084 Pfam : PF01340 SCOP : d1cmaa_, d1cmab_ UniProt : P0A8U6

Functional annotation:
Cellular component:	cytoplasm
Biological process:	methionine metabolic process amino acid biosynthetic process negative regulation of transcription, DNA-dependent transcription regulation of transcription, DNA-dependent regulation of transcription methionine biosynthetic process
Molecular function:	DNA binding transcription repressor activity transcription factor activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE

OverviewOverview

The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair DNA fragment. Sequence specificity is achieved by insertion of double-stranded antiparallel protein beta-ribbons into the major groove of B-form DNA, with direct hydrogen-bonding between amino-acid side chains and the base pairs. The repressor also recognizes sequence-dependent distortion or flexibility of the operator phosphate backbone, conferring specificity even for inaccessible base pairs.

About this StructureAbout this Structure

1CMA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:1406951 Page seeded by OCA on Fri May 2 12:53:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1cma.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1cma |SIZE=350|CAPTION= <scene name='initialview01'>1cma</scene>, resolution 2.800&Aring;
+The line below this paragraph, containing "STRUCTURE_1cma", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1cma|  PDB=1cma  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cma OCA], [http://www.ebi.ac.uk/pdbsum/1cma PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cma RCSB]</span>
-}}
 '''MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE'''
@@ Line 27: / Line 24: @@
 [[Category: Phillips, S E.V.]]
 [[Category: Somers, W S.]]
-[[Category: double helix]]
+[[Category: Double helix]]
-[[Category: protein-dna complex]]
+[[Category: Protein-dna complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:53:10 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:24:33 2008''