1ck7: Difference between revisions

Revision as of 12:49, 2 May 2008

GELATINASE A (FULL-LENGTH)

OverviewOverview

Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.

About this StructureAbout this Structure

1CK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed., Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K, Science. 1999 Jun 4;284(5420):1667-70. PMID:10356396 Page seeded by OCA on Fri May 2 12:49:27 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ck7.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ck7 |SIZE=350|CAPTION= <scene name='initialview01'>1ck7</scene>, resolution 2.8&Aring;
+The line below this paragraph, containing "STRUCTURE_1ck7", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1ck7|  PDB=1ck7  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ck7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ck7 OCA], [http://www.ebi.ac.uk/pdbsum/1ck7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ck7 RCSB]</span>
-}}
 '''GELATINASE A (FULL-LENGTH)'''
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 [[Category: Tryggvason, K.]]
 [[Category: Tuuttila, A.]]
-[[Category: full-length]]
+[[Category: Full-length]]
-[[Category: gelatinase some]]
+[[Category: Gelatinase some]]
-[[Category: hydrolase (metalloprotease)]]
+[[Category: Metalloproteinase]]
-[[Category: metalloproteinase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:49:27 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:23:11 2008''