1cjd: Difference between revisions

Revision as of 12:47, 2 May 2008

THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON

OverviewOverview

The unusual bacteriophage PRD1 features a membrane beneath its icosahedral protein coat. The crystal structure of the major coat protein, P3, at 1.85 A resolution reveals a molecule with three interlocking subunits, each with two eight-stranded viral jelly rolls normal to the viral capsid, and putative membrane-interacting regions. Surprisingly, the P3 molecule closely resembles hexon, the equivalent protein in human adenovirus. Both viruses also have similar overall architecture, with identical capsid lattices and attachment proteins at their vertices. Although these two dsDNA viruses infect hosts from very different kingdoms, their striking similarities, from major coat protein through capsid architecture, strongly suggest their evolutionary relationship.

About this StructureAbout this Structure

1CJD is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.

ReferenceReference

Viral evolution revealed by bacteriophage PRD1 and human adenovirus coat protein structures., Benson SD, Bamford JK, Bamford DH, Burnett RM, Cell. 1999 Sep 17;98(6):825-33. PMID:10499799 Page seeded by OCA on Fri May 2 12:47:52 2008

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OCA

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 [[Image:1cjd.gif|left|200px]]
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 '''THE BACTERIOPHAGE PRD1 COAT PROTEIN, P3, IS STRUCTURALLY SIMILAR TO HUMAN ADENOVIRUS HEXON'''
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 [[Category: Benson, S D.]]
 [[Category: Burnett, R M.]]
-[[Category: bacteriophage prd1]]
+[[Category: Bacteriophage prd1]]
-[[Category: coat protein]]
+[[Category: Coat protein]]
-[[Category: jelly roll]]
+[[Category: Jelly roll]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:47:52 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:22:49 2008''