1cj5: Difference between revisions
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'''BOVINE BETA-LACTOGLOBULIN A''' | '''BOVINE BETA-LACTOGLOBULIN A''' | ||
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[[Category: Hoshino, M.]] | [[Category: Hoshino, M.]] | ||
[[Category: Kuwata, K.]] | [[Category: Kuwata, K.]] | ||
[[Category: | [[Category: Beta-lactoglobulin some]] | ||
[[Category: | [[Category: Dynamic]] | ||
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Revision as of 12:47, 2 May 2008
BOVINE BETA-LACTOGLOBULIN A
OverviewOverview
Using heteronuclear NMR spectroscopy, we studied the solution structure and dynamics of bovine beta-lactoglobulin A at pH 2.0 and 45 degrees C, where the protein exists as a monomeric native state. The monomeric NMR structure, comprising an eight-stranded continuous antiparallel beta-barrel and one major alpha-helix, is similar to the X-ray dimeric structure obtained at pH 6.2, including betaI-strand that forms the dimer interface and loop EF that serves as a lid of the interior hydrophobic hole. [1H]-15N NOE revealed that betaF, betaG, and betaH strands buried under the major alpha-helix are rigid on a pico- to nanosecond time scale and also emphasized rapid fluctuations of loops and the N- and C-terminal regions.
About this StructureAbout this Structure
1CJ5 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure and dynamics of bovine beta-lactoglobulin A., Kuwata K, Hoshino M, Forge V, Era S, Batt CA, Goto Y, Protein Sci. 1999 Nov;8(11):2541-5. PMID:10595563 Page seeded by OCA on Fri May 2 12:47:25 2008