Insulin 3D Structures: Difference between revisions

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Revision as of 10:49, 25 August 2020

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Insulin
- 5bts, 4ak0, 2lgb, 1guj, 2c8r, 2c8q, 3i40, 3i3z, 5en9, 3zi3, 6s34, 6h3m, 6o17, 6s34 - hIns A chain + B chain – human
- 6jr3 - hIns A chain + B chain – Cryo EM
- 3e7y, 3e7z, 2qiu, 1os3, 1os4, 1mso, 1g7a, 1g7b, 1trz, 4eww, 4ewx, 4ewz, 4ex0, 4ex1, 4exx, 4ey1, 4ey9, 4eyd, 4eyn, 4eyp, 4f0n, 4f0o, 4f1a, 4f1b, 4f1c 4f1d, 4f1f, 4f1g, 4f4t, 4f4v, 4f51, 4f8f, 4fg3, 4p65, 2vjz, 2vk0, 3p33, 3w7y, 3w7z, 3w80, 5ems, 5e7w, 5co9, 5co6, 5co2, 6gv0 - hIns A chain + B chain + Zn
- 1fu2, 1fub - hIns A chain + B chain + Zn – powder diffraction
- 5t7r - hIns A chain (mutant) + B chain
- 1b9e, 3u4n, 4iuz, 4une, 4ung, 4unh, 5ena, 2ws4 - hIns A chain + B chain (mutant)
- 3bxq, 1qj0, 6tyh – hIns A chain + B chain (mutant) + Zn
- 3ir0, 3inc, 3ilg, 3exx, 2r34, 2r35, 2r36, 3tt8, 4rxw, 4fka, 6p4z - hIns A chain + B chain + non-Zn metal ion
- 1jca, 1j73, 4efx, - hIns A chain (mutant) + B chain + Zn
- 5mwq, 5azz, 6s4i, 6s4j, 6vet - hIns A chain (mutant) + B chain (mutant)
- 6p4z - hIns A chain + B chain + Co + Gd
- 2g4m, 9ins, 3t2a, 4a7e, 5lis, 5fb6, 5d5e, 5d54, 5d53, 5d52 - pIns A chain + B chain – pig
- 1iza - pIns A chain + B chain (mutant)
- 1zni, 4ins, 3ins, 3rto, 3fhp - pIns A chain + B chain + Zn
- 1izb - pIns A chain + B chain (mutant) + Zn
- 2zpp, 2efa - pIns A chain + B chain – Neutron
- 1m5a - pIns A chain + B chain + Co
- 6ins – pIns single chain
- 1aph, 1bph, 1cph, 1dph, 4bs3, 4i5y, 4i5z, 4ihn, 2bn1, 2bn3, 6qrh, 6qrk, 6qq7, 6qqg, 6or0, 6qq7, 6qqg, 6qrh, 6qrk - bIns A chain + B chain – bovine
- 2zp6, 4e7t, 4e7u, 4e7v, 4idw, 2a3g, - bIns A chain + B chain + Zn
- 4m4f, 4m4h, 4m4i, 4m4j, 4m4l, 4m4m - bIns A chain + B chain + non-Zn metal ion
- 6q8q - bIns A chain + B chain + Ar
Insulin structures using NMR
- 1sf1, 2aiy, 3aiy, 4aiy, 5aiy, 1xgl, 2mvc, 2kxk, 2m1e, 2m2m, 2m2n, 2m2o, 2m2p, 2hiu, 2jv1, 6x4x - hIns A chain + B chain – NMR
- 1ai0, 1aiy - hIns A chain + B chain + Zn – NMR
- 1t1k, 1t1p, 1t1q, 2mpg, 2mpi, 2l1z, 5mhd - hIns A chain (mutant) + B chain – NMR
- 2jmn, 2h67, 2hho, 1jco, 1a7f, 2mvd, 2kjj, 2k91, 2rn5, 1hiq, 1hit - hIns A chain + B chain (mutant) – NMR
- 2jum, 2juv, 1k3m, 1vkt, 1hui, 1mhi, 1mhj, 1hls, 1lkq, 2m1d - hIns A chain (mutant) + B chain (mutant) – NMR
- 2kqq, 2l1y - hIns A chain (mutant) + B chain + Ala – NMR
- 2kjr - hIns A chain + B chain (mutant) + Ala – NMR
- 2hh4 - hIns A chain + B chain (mutant) + Ser – NMR
- 2kju - hIns A chain + B chain (mutant) + Glu – NMR
- 2juu - hIns A chain (mutant) + B chain (mutant) + Thr – NMR
- 1kmf - hIns A chain (mutant) + B chain (mutant) + Ile – NMR
- 1bzv - hIns A chain (mutant) + B chain (mutant) + Ala – NMR
- 2lwz, 5wbt – hIns single chain - NMR
- 2jzq – hIns single chain (mutant) - NMR
- 1ho0 - bIns B chain (mutant) – NMR
- 5miz, 6kh9, 6kha - bIns A chain + B chain – NMR
Insulin complexes
- 4xc4 - hIns A chain + B chain + sulfatide + Zn
- 1ben - hIns A chain + B chain + hydroxybenzamide + Zn
- 1tyl, 1tym - hIns A chain + B chain + hydroxyacetanilide + Zn
- 5boq - hIns A chain + B chain + norleucine
- 5bpo - hIns A chain + B chain + norvaline
- 5bqq - hIns A chain + B chain + norvaline + Zn
- 2mli - hIns A chain + B chain + Phe derivative
- 2ws1 - hIns A chain + B chain + Tyr derivative
- 5hqi, 5hpr, 4cxl, 2wrw - hIns A chain + B chain (mutant) + Pro derivative
- 4nib - hIns A chain (mutant) + B chain + Ala
- 3fq9 - hIns A chain (mutant) + B chain + Ala + Zn
- 4cxn, 4cy7, 2wru, 2wrx, 2ws0 - hIns A chain + B chain (mutant) + Ala derivative
- 2wrv - hIns A chain + B chain (mutant) + His derivative
- 2oly, 2om0, 2omh, 2omi - hIns A chain + B chain + urea + resorcinol + Zn
- 2omg - hIns A chain + B chain + urea + cresol + Zn
- 2olz, 2om1 - hIns A chain + B chain + thiocyanate + resorcinol + Zn
- 4akj, 4ajz, 3v19, 1znj - hIns A chain + B chain + phenol + Zn
- 3kq6, 1xw7, 1rwe - hIns A chain (mutant) + B chain + phenol + Zn
- 1w8p, 2ws7, 1qiy - hIns A chain + B chain (mutant) + phenol + Zn
- 1zeg, 1lph - hIns A chain (mutant) + B chain (mutant) + phenol + Zn
- 3v1g - hIns A chain + B chain + phenol + Glu + Zn
- 1q4v - hIns A chain + B chain + phenol + Ile + Zn
- 3rov, 3p2x - hIns A chain + B chain (mutant) + phenol + Ala + Zn
- 5hpu, 5uu4, 5uu3, 5uu2, 5usv, 5uss, 5usp, 5uru, 5urt, 5uqa, 5uoz - hIns A chain + B chain + phenol + Pro derivative + Zn
- 5hrq - hIns A chain + B chain (mutant) + phenol + Pro derivative + Zn
- 3zs2, 3zqr - hIns A chain + B chain + phenol + Phe derivative + Zn
- 2ws6 - hIns A chain + B chain + phenol + Tyr derivative + Zn
- 1xda - hIns A chain + B chain + phenol + myristic acid + Zn
- 6ck2 - hIns A chain + B chain (mutant) + phenol + ornithine + Zn
- 1qiz - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn
- 1ev3, 1ev6, 1uz9, 4gbn, 4gbc, 4gbi, 4gbk, 4gbl, 6gnq - hIns A chain + B chain + cresol + Zn
- 1zeh - hIns A chain (mutant) + B chain (mutant) + cresol + Zn
- 1evr, 4ajx, 3zu1 - hIns A chain + B chain + resorcinol + Zn
- 3q6e - hIns A chain + B chain + synthetic receptor
- 2g54, 2g56 - hIns B chain + insulin-degrading enzyme + Zn
- 6b3q - hIns A chain + B chain + insulin-degrading enzyme
- 6bfc - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM
- 2wby, 2wc0 - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn
- 3w11, 5kqv - hIns A chain + B chain + insulin-degrading enzyme + antibody
- 5wob - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn
- 4oga, 6vep - hIns A chain + B chain + insulin receptor + antibody
- 6ce7, 6ce9, 6ceb, 6hn5 - hIns A chain + B chain + insulin receptor – Cryo EM
- 5mam - hIns A chain + B chain + serotonin + Zn
- 5mt9, 5mt3 - hIns A chain + B chain + serotonin + arginine + Zn
- 1b17, 1b18, 1b19, 1b2a, 1b2b, 1b2c, 1b2d, 1b2e, 1b2f, 1b2g - pIns A chain + B chain + sulfate
- 1mpj, 3gky, 1wav - pIns A chain + B chain + phenol + Zn
- 2tci - pIns A chain + B chain + thiocyanate + Zn
- 3mth - pIns A chain + B chain + methylparaben + Zn
- 7ins - pIns A chain + B chain + clupeine + cresol + Zn
- 5jyq - CgIns A chain + B chain + Pro derivative – Conus geographus
- 6veq - CgIns A chain + B chain + insulin receptor + antibody
Proinsulin
- 2kqp – hPIns A chain – NMR
- 1t0c - hPIns A chain residues 57-87 – NMR
- 1iog, 1ioh, 1sjt - hPIns A chain (mutant) + B chain (mutant) – NMR
- 1efe – mini-hPIns
- 1sju - mini-hPIns (mutant)
Despeptide insulin
- 1his - hDPI A chain + B chain]] - NMR
- 1htv – hDTRI A chain + B chain
- 1sdb - pDPI A chain + B chain
- 1dei – pDHPI A chain (mutant) + B chain (mutant)
- 1pid - bDPI A chain + B chain
- 2ins – bD-Phe Ins chain A + chain B
- 2ceu – DPI – yeast
Leginsulin
- 1ju8 – Lins A chain residues 1-37 – legume - NMR
Insulin lispro
- 5udp – LishIns – synthetic
- 6nwv - hIns A chain + hInsLis B chain + cresol + Zn
Insulin glargine
- 4iyd, 4iyf, 5viz – hIns – synthetic

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Michal Harel, Joel L. Sussman

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 * Insulin
-**[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]], [[6s34]], [[6h3m]] - hIns A chain + B chain – human<br />
+**[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]], [[6s34]], [[6h3m]], [[6o17]], [[6s34]] - hIns A chain + B chain – human<br />
+**[[6jr3]] - hIns A chain + B chain – Cryo EM<br />
 **[[3e7y]], [[3e7z]], [[2qiu]], [[1os3]], [[1os4]], [[1mso]], [[1g7a]], [[1g7b]], [[1trz]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[2vjz]], [[2vk0]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[6gv0]] - hIns A chain + B chain + Zn<br />
 **[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br />
 **[[5t7r]] - hIns A chain (mutant) + B chain<br />
-**[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]] - hIns A chain + B chain (mutant)<br />
+**[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[2ws4]] - hIns A chain + B chain (mutant)<br />
-**[[3bxq]], [[1qj0]] – hIns A chain + B chain (mutant) + Zn
+**[[3bxq]], [[1qj0]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn
 **[[3ir0]], [[3inc]], [[3ilg]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]], [[4rxw]], [[4fka]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br />
 **[[1jca]], [[1j73]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br />
-**[[5ena]], [[2ws4]] - hIns A chain + B chain (mutant)<br />
+**[[5mwq]], [[5azz]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br />
-**[[5mwq]], [[5azz]] - hIns A chain (mutant) + B chain (mutant)<br />
+**[[6p4z]] - hIns A chain + B chain + Co + Gd<br />
 **[[2g4m]], [[9ins]], [[3t2a]], [[4a7e]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<br />
 **[[1iza]] - pIns A chain + B chain (mutant)<br />
@@ Line 20: / Line 21: @@
 **[[1m5a]] - pIns A chain + B chain + Co<br />
 **[[6ins]] – pIns single chain<br />
-**[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]], [[6qrh]], [[6qrk]], [[6qq7]], [[6qqg]] - bIns A chain + B chain – bovine<br />
+**[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]], [[6qrh]], [[6qrk]], [[6qq7]], [[6qqg]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br />
 **[[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[2a3g]], - bIns A chain + B chain + Zn <br />
 **[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br />
+**[[6q8q]] - bIns A chain + B chain + Ar <br />
 *Insulin structures using NMR
-**[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]] - hIns A chain + B chain – NMR<br />
+**[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]], [[6x4x]] - hIns A chain + B chain – NMR<br />
 **[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br />
 **[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br />
@@ Line 41: / Line 43: @@
 **[[2jzq]] – hIns single chain (mutant) - NMR<br />
 **[[1ho0]] - bIns B chain (mutant) – NMR<br />
-**[[5miz]] - bIns A chain + B chain – NMR<br />
+**[[5miz]], [[6kh9]], [[6kha]] - bIns A chain + B chain – NMR<br />
 *Insulin complexes
@@ Line 58: / Line 60: @@
 **[[4cxn]], [[4cy7]], [[2wru]], [[2wrx]], [[2ws0]] - hIns A chain + B chain (mutant) + Ala derivative<br />
 **[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br />
-**[[5jyq]] - Ins A chain + B chain + Pro derivative – Conus geographus<br />
 **[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br />
 **[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br />
@@ Line 86: / Line 87: @@
 **[[3w11]], [[5kqv]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
 **[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br />
-**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br />
+**[[4oga]], [[6vep]] - hIns A chain + B chain + insulin receptor + antibody<br />
 **[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
 **[[5mam]] - hIns A chain + B chain + serotonin + Zn<br />
@@ Line 95: / Line 96: @@
 **[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br />
 **[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br />
+**[[5jyq]] - CgIns A chain + B chain + Pro derivative – ''Conus geographus''<br />
+**[[6veq]] - CgIns A chain + B chain + insulin receptor + antibody<br />
 * Proinsulin
@@ Line 120: / Line 123: @@
 *Insulin lispro
-**[[5udp]] – hIns – synthetic<br />
+**[[5udp]] – LishIns – synthetic<br />
+**[[6nwv]] - hIns A chain + hInsLis B chain + cresol + Zn<br />
 *Insulin glargine

Insulin 3D Structures: Difference between revisions

Revision as of 10:49, 25 August 2020

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