1cfq: Difference between revisions
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'''ANTI-P24 (HIV-1) FAB FRAGMENT CB41''' | '''ANTI-P24 (HIV-1) FAB FRAGMENT CB41''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFQ OCA]. | |||
==Reference== | ==Reference== | ||
Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9413990 9413990] | Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9413990 9413990] | ||
[[Category: Hoehne, W.]] | [[Category: Hoehne, W.]] | ||
[[Category: Keitel, T.]] | [[Category: Keitel, T.]] | ||
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[[Category: Scholz, C.]] | [[Category: Scholz, C.]] | ||
[[Category: Wessner, H.]] | [[Category: Wessner, H.]] | ||
[[Category: | [[Category: Cross reactivity]] | ||
[[Category: | [[Category: Fab-fragment]] | ||
[[Category: | [[Category: Hiv-1]] | ||
[[Category: | [[Category: Peptide]] | ||
[[Category: | [[Category: Polyspecificity]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:41:17 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 12:41, 2 May 2008
ANTI-P24 (HIV-1) FAB FRAGMENT CB41
OverviewOverview
The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2.6 A. The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:9413990 Page seeded by OCA on Fri May 2 12:41:17 2008