6vxp: Difference between revisions
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==Cryo-EM structure of Arabidopsis thaliana MSL1 in lipid nanodisc== | ==Cryo-EM structure of Arabidopsis thaliana MSL1 in lipid nanodisc== | ||
<StructureSection load='6vxp' size='340' side='right'caption='[[6vxp]]' scene=''> | <StructureSection load='6vxp' size='340' side='right'caption='[[6vxp]], [[Resolution|resolution]] 3.39Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VXP FirstGlance]. <br> | <table><tr><td colspan='2'>[[6vxp]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VXP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VXP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vxp OCA], [http://pdbe.org/6vxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vxp RCSB], [http://www.ebi.ac.uk/pdbsum/6vxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vxp ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MSL1, At4g00290, A_IG005I10.9, F5I10.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vxp OCA], [http://pdbe.org/6vxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vxp RCSB], [http://www.ebi.ac.uk/pdbsum/6vxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vxp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MSL1_ARATH MSL1_ARATH]] Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including hearing, touch, proprioception, osmoregulation, and morphogenesis. The mechanosensitive channels of small conductance (MscS) constitute a remarkably diverse superfamily of channels critical for management of osmotic pressure. Here, we present cryo-electron microscopy structures of a MscS homolog from Arabidopsis thaliana, MSL1, presumably in both the closed and open states. The heptameric MSL1 channel contains an unusual bowl-shaped transmembrane region, which is reminiscent of the evolutionarily and architecturally unrelated mechanosensitive Piezo channels. Upon channel opening, the curved transmembrane domain of MSL1 flattens and expands. Our structures, in combination with functional analyses, delineate a structural mechanism by which mechanosensitive channels open under increased membrane tension. Further, the shared structural feature between unrelated channels suggests the possibility of a unified mechanical gating mechanism stemming from membrane deformation induced by a non-planar transmembrane domain. | |||
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.,Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P Nat Commun. 2020 Jul 23;11(1):3690. doi: 10.1038/s41467-020-17538-1. PMID:32704140<ref>PMID:32704140</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6vxp" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arath]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Deng Z]] | [[Category: Deng, Z]] | ||
[[Category: Yuan P]] | [[Category: Yuan, P]] | ||
[[Category: Zhang J]] | [[Category: Zhang, J]] | ||
[[Category: Ion channel]] | |||
[[Category: Transport protein]] | |||