SARS-CoV-2 spike protein fusion transformation: Difference between revisions
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The <scene name='85/857791/Pre-fusion_6xr8/1'>SARS-CoV-2 spike protein pre-fusion conformation</scene> is a homo-trimer, each chain having a mature length of 1,261 amino acids. This pre-fusion cryo-EM structure [[6xr8]] is complete except for 110 residues of the C-terminus (narrow end), comprising 48 residues of the stem (heptad repeat 2 domain), a 23-residue trans-membrane domain, and a 39 residue cytoplasmic domain. | The <scene name='85/857791/Pre-fusion_6xr8/1'>SARS-CoV-2 spike protein pre-fusion conformation</scene> is a homo-trimer, each chain having a mature length of 1,261 amino acids. This pre-fusion cryo-EM structure [[6xr8]] is complete except for 110 residues of the C-terminus (narrow end), comprising 48 residues of the stem (heptad repeat 2 domain), a 23-residue trans-membrane domain, and a 39 residue cytoplasmic domain. | ||
<scene name='85/857791/Pre-fusion_6xr8/4'>Domains are colored</scene> ( | <scene name='85/857791/Pre-fusion_6xr8/4'>Domains are colored</scene> (as in Cai, Zhang et al. <ref name="cai-zhang" />; '''lengths'''): | ||
* 14-306 ('''293'''): <b><font color="#0040e0">N-terminal domain</font></b>. | * 14-306 ('''293'''): <b><font color="#0040e0">N-terminal domain</font></b>. | ||
* 307-330 ('''24'''): <b><font color="#808080">Linker</font></b>. | * 307-330 ('''24'''): <b><font color="#808080">Linker</font></b>. | ||