SARS-CoV-2 spike protein fusion transformation: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Karsten Theis

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 The <scene name='85/857791/Pre-fusion_6xr8/1'>SARS-CoV-2 spike protein pre-fusion conformation</scene> is a homo-trimer, each chain having a mature length of 1,261 amino acids. This pre-fusion cryo-EM structure [[6xr8]] is complete except for 110 residues of the C-terminus (narrow end), comprising 48 residues of the stem (heptad repeat 2 domain), a 23-residue trans-membrane domain, and a 39 residue cytoplasmic domain.
-<scene name='85/857791/Pre-fusion_6xr8/3'>Domains are colored</scene> (from Cai, Zhang et al. <ref name="cai-zhang" />; '''lengths'''):
+<scene name='85/857791/Pre-fusion_6xr8/4'>Domains are colored</scene> (from Cai, Zhang et al. <ref name="cai-zhang" />; '''lengths'''):
 * 14-306 ('''293'''): <b><font color="#0040e0">N-terminal domain</font></b>.
 * 307-330 ('''24'''): <b><font color="#808080">Linker</font></b>.
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 * 529-591 ('''63'''): <b><font color="#00a000">CTD1</font></b> (C terminal region of S1 fragment after furin cleavage).
 * 592-676 ('''85'''): <b><font color="#60d060">CTD2</font></b> (C terminus of S1 fragment after furin cleavage).
-* 677-688 ('''12'''): Furin cleavage site PRRAR (missing in this model due to disorder).
+* 677-688 ('''12'''): <b><font color="#ff8080">Pink balls</font></b> mark the furin cleavage site PRRAR (missing in this model due to disorder).
 * 689-816 ('''128'''): <b><font color="#b0bf80">Linker</font></b>
 * 817-825 ('''9'''): <b><font color="#00c0c0">Fusion peptide (FP)</font></b>.