6v8w: Difference between revisions
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==CDYL2 chromodomain in complex with a synthetic peptide== | ==CDYL2 chromodomain in complex with a synthetic peptide== | ||
<StructureSection load='6v8w' size='340' side='right'caption='[[6v8w]]' scene=''> | <StructureSection load='6v8w' size='340' side='right'caption='[[6v8w]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8W FirstGlance]. <br> | <table><tr><td colspan='2'>[[6v8w]] is a 52 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8W FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8w OCA], [http://pdbe.org/6v8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8w RCSB], [http://www.ebi.ac.uk/pdbsum/6v8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8w ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5T3:'>5T3</scene>, <scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDYL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8w OCA], [http://pdbe.org/6v8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8w RCSB], [http://www.ebi.ac.uk/pdbsum/6v8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8w ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The CDY (chromodomain on the Y) proteins play an essential role in normal spermatogenesis and brain development. Dysregulation of their expression has been linked to male infertility and various neurological diseases. Like the chromodomains of HP1 and Polycomb, the CDY chromodomains also recognize the lysine-methylated ARKS motif embedded in histone and non-histone proteins. Interestingly, the CDY chromodomains exhibit different binding preferences for the lysine-methylated ARKS motif in different sequence contexts. Here, we present the structural basis for selective binding of CDY1 to H3K9me3 and preferential binding of CDYL2 to H3tK27me3 over H3K27me3. In addition, we use a CDYL1/2-selective compound, UNC4850, to gain further insight into the molecular mechanisms underlying CDYL2 binding specificity. Our work also provides critical implications that CDYL1b's role in the regulation of neural development is dependent on its recognition of the lysine-methylated ARKS motif. | |||
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.,Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J Cell Chem Biol. 2020 May 26. pii: S2451-9456(20)30153-7. doi:, 10.1016/j.chembiol.2020.05.007. PMID:32470319<ref>PMID:32470319</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6v8w" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra C | [[Category: Bountra, C]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Tempel W]] | [[Category: Dong, C]] | ||
[[Category: Edwards, A M]] | |||
[[Category: James, L I]] | |||
[[Category: Lamb, K N]] | |||
[[Category: Min, J]] | |||
[[Category: Tempel, W]] | |||
[[Category: Chromodomain]] | |||
[[Category: Protein binding]] | |||
[[Category: Sgc]] | |||