6d3t: Difference between revisions

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<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6d3t' size='340' side='right'caption='[[6d3t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D3T FirstGlance]. <br>
<table><tr><td colspan='2'>[[6d3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D3T FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [http://pdbe.org/6d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [http://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3t OCA], [http://pdbe.org/6d3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3t RCSB], [http://www.ebi.ac.uk/pdbsum/6d3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>   
[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>   
==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buthus tamalus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Delgado, G Titaux]]
[[Category: Delgado, G Titaux]]

Revision as of 14:18, 29 July 2020

NMR solution structure of tamapin, mutant DP30NMR solution structure of tamapin, mutant DP30

Structural highlights

6d3t is a 1 chain structure with sequence from Buthus tamalus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KAX54_MESTA] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.[1]

See Also

References

  1. ↑ Pedarzani P, D'hoedt D, Doorty KB, Wadsworth JD, Joseph JS, Jeyaseelan K, Kini RM, Gadre SV, Sapatnekar SM, Stocker M, Strong PN. Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277(48):46101-9. Epub 2002 Sep 17. PMID:12239213 doi:http://dx.doi.org/10.1074/jbc.M206465200
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