Proteopedia:Featured SEL/5: Difference between revisions
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<tr><td><div class='scrolling '>'''Coronavirus Spike Protein Priming'''<br> | <tr><td><div class='scrolling '>'''Coronavirus Spike Protein Priming'''<br> | ||
''by Eric Martz''<br> | ''by Eric Martz''<br> | ||
Coronavirus SARS-CoV-2 (responsible for COVID-19) has a spike protein on its surface, which enables it to infect host cells. Initially, proteases in the lungs clip the homo-trimeric spike protein at a <font color="red">'''unique sequence'''</font>. This primes it, causing it to extend its <font color="magenta">'''receptor binding surface'''</font>, optimizing binding to the host cell's ACE2 receptor (not shown). Next, spike protein initiates fusion of the virus and host cell membranes (not shown), enabling the virus RNA to enter the cell and initiate production of new virions. Knowledge of spike protein's molecular structure and function is crucial to developing effective therapies and vaccines. | Coronavirus SARS-CoV-2 (responsible for COVID-19) has a spike protein on its surface, which enables it to infect host cells. Initially, proteases in the lungs clip the homo-trimeric spike protein at a <font color="red">'''unique sequence'''</font>. This primes it, causing it to extend its <font color="magenta">'''receptor binding surface'''</font> (shown in animation above), optimizing binding to the host cell's ACE2 receptor (not shown). Next, spike protein initiates fusion of the virus and host cell membranes (not shown), enabling the virus RNA to enter the cell and initiate production of new virions. Knowledge of spike protein's molecular structure and function is crucial to developing effective therapies and vaccines. | ||
>>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>> | >>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>> | ||
</div> | </div> | ||
Revision as of 22:53, 28 July 2020
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Coronavirus Spike Protein Priming
by Eric Martz |