Proteopedia:Featured SEL/5: Difference between revisions

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<tr><td><div class='scrolling '>'''SARS-CoV-2 protein S priming by furin'''<br>
<tr><td><div class='scrolling '>'''SARS-CoV-2 Spike Protein Priming'''<br>
''by Eric Martz''<br>
''by Eric Martz''<br>
Many copies of the spike protein of the coronavirus that causes COVID-19 are seen, in the electron microscope, sticking out from the surface of the virion (virus particle), making it look somewhat like a crown -- hence the name coronavirus. The spike protein is called protein S of the SARS-CoV-2 virus, and plays a central role in binding to host cells, and getting the RNA genes of the virus into the cell, initiating infection. Thus, knowledge of its protein molecular structure and function is crucial to developing effective therapies and vaccines.
Coronavirus SARS-CoV-2 (responsible for COVID-19) has a spike protein on its surface enabling it to infect host cells. Initially, proteases in the lungs clip the spike protein at a <font color="red">'''unique sequence'''</font>. This primes it, causing it to extend its <font color="magenta">'''receptor binding surface'''</font>, optimizing binding to the ACE2 receptor on the host cell. In a subsequent step (not shown) the virus RNA enters the cell to initiate production of new virions. Knowledge of spike protein's protein molecular structure and function is crucial to developing effective therapies and vaccines.
 
>>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>>
>>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>>
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Revision as of 22:24, 28 July 2020

SARS-CoV-2 Spike Protein Priming

by Eric Martz
Coronavirus SARS-CoV-2 (responsible for COVID-19) has a spike protein on its surface enabling it to infect host cells. Initially, proteases in the lungs clip the spike protein at a unique sequence. This primes it, causing it to extend its receptor binding surface, optimizing binding to the ACE2 receptor on the host cell. In a subsequent step (not shown) the virus RNA enters the cell to initiate production of new virions. Knowledge of spike protein's protein molecular structure and function is crucial to developing effective therapies and vaccines. >>> Visit this page >>>

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Jaime Prilusky, Eric Martz
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