1c35: Difference between revisions
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{{STRUCTURE_1c35| PDB=1c35 | SCENE= }} | |||
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'''SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE''' | '''SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE''' | ||
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==About this Structure== | ==About this Structure== | ||
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C35 OCA]. | |||
==Reference== | ==Reference== | ||
Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10756199 10756199] | Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10756199 10756199] | ||
[[Category: Bolton, P H.]] | [[Category: Bolton, P H.]] | ||
[[Category: Marathias, V M.]] | [[Category: Marathias, V M.]] | ||
[[Category: Wang, K.]] | [[Category: Wang, K.]] | ||
[[Category: | [[Category: Aptamer]] | ||
[[Category: | [[Category: Intermediate]] | ||
[[Category: | [[Category: Metal binding site]] | ||
[[Category: | [[Category: Potassium]] | ||
[[Category: | [[Category: Quadruplex]] | ||
[[Category: | [[Category: Thrombin binding]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:16:23 2008'' | |||
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Revision as of 12:16, 2 May 2008
SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE
OverviewOverview
Potassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat and other DNAs, information about the details of the potassium-quadruplex DNA interactions are of interest. The structures of the 1:1 and the fully saturated, 2:1, potassium-DNA complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination of experimental NMR results and restrained molecular dynamics simulations. The refined structures have been used to model the interactions at the potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA structures indicates how potassium binding can determine the folding pattern of the DNA. In each binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and the guanine residues of the adjacent quartet.
About this StructureAbout this Structure
Full crystallographic information is available from OCA.
ReferenceReference
Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199 Page seeded by OCA on Fri May 2 12:16:23 2008