1c1y: Difference between revisions

Revision as of 12:14, 2 May 2008

CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).

OverviewOverview

The X-ray crystal structure of the complex between the Ras-related protein Rap1A in the GTP-analogue (GppNHp) form and the Ras-binding domain (RBD) of the Ras effector molecule c-Raf1, a Ser/Thr-specific protein kinase, has been solved to a resolution of 2.2 A. It shows that RBD has the ubiquitin superfold and that the structure of Rap1A is very similar to that of Ras. The interaction between the two proteins is mediated by an apparent central antiparallel beta-sheet formed by strands B1-B2 from RBD and strands beta 2-beta 3 from Rap1A. Complex formation is mediated by main-chain and side-chain interactions of the so-called effector residues in the switch I region of Rap1A.

About this StructureAbout this Structure

1C1Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue., Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A, Nature. 1995 Jun 15;375(6532):554-60. PMID:7791872 Page seeded by OCA on Fri May 2 12:14:09 2008

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OCA

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 [[Image:1c1y.gif|left|200px]]
- {{Structure
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-}}
 '''CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).'''
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 [[Category: Protein complex]]
 [[Category: Nassar, N.]]
-[[Category: effector]]
+[[Category: Effector]]
-[[Category: gtp-binding protein]]
+[[Category: Gtp-binding protein]]
-[[Category: protein-protein complex]]
+[[Category: Protein-protein complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:14:09 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:12:55 2008''