Bromodomain-containing protein 3D structures: Difference between revisions
Michal Harel (talk | contribs) New page: == 3D Structures of bromodomain-containing protein == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Bromodomain-... |
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**[[2dvq]], [[2dvr]], [[2dvs]], [[2e3k]] – hBRD2 bromodomain 1 + histone H4 peptide<br /> | **[[2dvq]], [[2dvr]], [[2dvs]], [[2e3k]] – hBRD2 bromodomain 1 + histone H4 peptide<br /> | ||
**[[3oni]] – hBRD2 residues 224-335 + inhibitor<br /> | **[[3oni]] – hBRD2 residues 224-335 + inhibitor<br /> | ||
**[[3aqa]], [[2ydw]], [[2yek]], [[4a9e]], [[4a9f]], [[4a9h]], [[4a9i]], [[4a9j]], [[4a9m]], [[4a9n]], [[4a9o]], [[4alh]], [[4akn]], [[4alg]], [[4uyf]], [[4uyg]], [[4uyh]] – hBRD2 N-terminal bromodomain + inhibitor<br /> | **[[3aqa]], [[2ydw]], [[2yek]], [[4a9e]], [[4a9f]], [[4a9h]], [[4a9i]], [[4a9j]], [[4a9m]], [[4a9n]], [[4a9o]], [[4alh]], [[4akn]], [[4alg]], [[4uyf]], [[4uyg]], [[4uyh]], [[6db0]], [[6ddi]], [[6k05]], [[6ony]] – hBRD2 N-terminal bromodomain + inhibitor<br /> | ||
**[[4mr5]], [[4mr6]], [[4j1p]], [[5ig6]], [[5ek9]], [[5dw1]], [[5xhk]], [[5xhe]], [[5u6v]], [[5n2l]], [[6mo7]], [[6mo8]], [[6mo9]], [[6moa]] – hBRD2 bromodomain 2 + inhibitor<br /> | **[[4mr5]], [[4mr6]], [[4j1p]], [[5ig6]], [[5ek9]], [[5dw1]], [[5xhk]], [[5xhe]], [[5u6v]], [[5n2l]], [[6mo7]], [[6mo8]], [[6mo9]], [[6moa]], [[6dbc]], [[6ddj]], [[6e6j]], [[6fff]], [[6k04]], [[6viy]] – hBRD2 bromodomain 2 + inhibitor<br /> | ||
**[[5o3i]], [[5o3h]], [[5o3g]], [[5o3f]], [[5o3e]], [[5o3d]], [[5o3c]], [[5o3b]], [[5o3a]], [[5o39]], [[5o38]] – hBRD2 bromodomain 2 (mutant) + inhibitor<br /> | **[[5o3i]], [[5o3h]], [[5o3g]], [[5o3f]], [[5o3e]], [[5o3d]], [[5o3c]], [[5o3b]], [[5o3a]], [[5o39]], [[5o38]], [[6ytm]] – hBRD2 bromodomain 2 (mutant) + inhibitor<br /> | ||
**[[5u5s]] – hBRD2 bromodomain 2 + STAT3 peptide - NMR<br /> | **[[5u5s]] – hBRD2 bromodomain 2 + STAT3 peptide - NMR<br /> | ||
**[[5bt5]] – hBRD2 bromodomain 2 + probe<br /> | **[[5bt5]] – hBRD2 bromodomain 2 + probe<br /> | ||
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**[[2nxb]] – hBRD3 bromodomain 1<br /> | **[[2nxb]] – hBRD3 bromodomain 1<br /> | ||
**[[2yw5]] – hBRD3 bromodomain 1 - NMR<br /> | **[[2yw5]] – hBRD3 bromodomain 1 - NMR<br /> | ||
**[[3s91]], [[3s92]] | **[[3s91]], [[3s92]], [[6qju]] – hBRD3 bromodomain 1 + inhibitor<br /> | ||
**[[2oo1]] – hBRD3 bromodomain 2<br /> | **[[2oo1]] – hBRD3 bromodomain 2<br /> | ||
**[[2e7n]] – hBRD3 bromodomain 2 - NMR<br /> | **[[2e7n]] – hBRD3 bromodomain 2 - NMR<br /> | ||
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**[[6bgh]] – hBRD3 ET domain + BRG1 peptide - NMR<br /> | **[[6bgh]] – hBRD3 ET domain + BRG1 peptide - NMR<br /> | ||
**[[6bgg]] – hBRD3 ET domain + CHD4 peptide - NMR<br /> | **[[6bgg]] – hBRD3 ET domain + CHD4 peptide - NMR<br /> | ||
**[[2l5e]] – mBRD3 bromodomain 1 + GATA-1 C-terminal – mouse - NMR<br /> | |||
*Bromodomain-containing protein 4 | *Bromodomain-containing protein 4 | ||
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*Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex | *Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex | ||
**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br /> | **[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br /> | ||
**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br /> | **[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br /> | ||
**[[6g0o]], [[6g0p]], [[6g0q]], [[6g0r]], [[6g0s]], [[5nng]], [[5nnf]], [[5nne]] – hBRD4 bromodomain 1 + peptide<br /> | **[[6g0o]], [[6g0p]], [[6g0q]], [[6g0r]], [[6g0s]], [[5nng]], [[5nnf]], [[5nne]] – hBRD4 bromodomain 1 + peptide<br /> | ||
**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]], [[6q3y]], [[6q3z]], [[6mau]], [[6hdq]], [[6fnx]], [[6fo5]], [[6fsy]], [[6ft3]], [[6ft4]], [[6e4a]], [[6dmj]], [[6dml]], [[6djc]], [[6czu]], [[6czv]], [[6ckr]], [[6cks]], [[6cis]], [[6ciy]], [[6cj1]], [[6cj2]], [[6cd4]], [[6cd5]], [[6afr]], [[5z1r]], [[5z1s]], [[5z1t]], [[5z5t]], [[5z5u]], [[5z5v]], [[5z8g]], [[5z8r]], [[5z8z]], [[5z90]], [[5z9k]], [[5yqx]], [[5y93]], [[5y94]], [[5y8c]], [[5y8w]], [[5y8w]], [[5y8y]], [[5y8z]], [[5xhy]], [[5xi2]], [[5xi3]], [[5xi4]], [[5wma]], [[5wa5]], [[5w55]], [[5vzs]], [[5vbp]], [[5vbo]], [[5ovb]], [[5o97]], [[6ajv]], [[6ajw]], [[6ajx]], [[6ajy]], [[6dl2]], [[6i7x]], [[67iy]], [[6in1]], [[6in2]], [[6ji3]], [[6ji4]], [[6ji5]], [[6jj3]], [[6jj5]], [[6jj6]], [[6jjb]], [[6mh1]], [[6mh7]], [[6p05]], [[6prt]], [[6ps9]], [[6psb]], [[6s25]], [[6se4]], [[6uvj]], [[6uvm]], [[6uwu]], [[6uwx]], [[6v0u]], [[6v1k]], [[6v1l]], [[6v1u]], [[6viw]], [[6vix]], [[6vub]], [[6vuc]], [[6vuf]], [[6vuj]], [[6yin]], [[6yqn]], [[6yqo]], [[6yqp]] – hBRD4 bromodomain 1 + inhibitor<br /> | |||
**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]], [[6q3y]], [[6q3z]], [[6mau]], [[6hdq]], [[6fnx]], [[6fo5]], [[6fsy]], [[6ft3]], [[6ft4]], [[6e4a]], [[6dmj]], [[6dml]], [[6djc]], [[6czu]], [[6czv]], [[6ckr]], [[6cks]], [[6cis]], [[6ciy]], [[6cj1]], [[6cj2]], [[6cd4]], [[6cd5]], [[6afr]], [[5z1r]], [[5z1s]], [[5z1t]], [[5z5t]], [[5z5u]], [[5z5v]], [[5z8g]], [[5z8r]], [[5z90]], [[5z9k]], [[5yqx]], [[5y93]], [[5y94]], [[5y8c]], [[5y8w]], [[5y8w]], [[5y8y]], [[5y8z]], [[5xhy]], [[5xi2]], [[5xi3]], [[5xi4]], [[5wma]], [[5wa5]], [[5w55]], [[5vzs]], [[5vbp]], [[5vbo]], [[5ovb]], [[5o97]] – hBRD4 bromodomain 1 + inhibitor<br /> | **[[6g0d]], [[6g0e]], [[6g0f]], [[6g0g]], [[6g0h]], [[6hov]] – hBRD4 bromodomain 1 (mutant) + inhibitor<br /> | ||
**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br /> | **[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br /> | ||
**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br /> | **[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br /> | ||
**[[4lys]], [[4lzr]] – hBRD4 bromodomain 1 + colchiceine<br /> | **[[4lys]], [[4lzr]], [[6ajz]] – hBRD4 bromodomain 1 + colchiceine<br /> | ||
**[[4qb3]] – hBRD4 bromodomain 1 + olinone<br /> | **[[4qb3]] – hBRD4 bromodomain 1 + olinone<br /> | ||
**[[4whw]] – hBRD4 bromodomain 1 + probe<br /> | **[[4whw]] – hBRD4 bromodomain 1 + probe<br /> | ||
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**[[5hcl]] – hBRD4 bromodomain 1 + drug<br /> | **[[5hcl]] – hBRD4 bromodomain 1 + drug<br /> | ||
**[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br /> | **[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br /> | ||
**[[3jvk]], [[3muk]], [[3mul]], [[5nnd]], [[5nnc]] – mBRD4 bromodomain 1 + histone H3.3 peptide<br /> | |||
**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br /> | |||
**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br /> | |||
**[[3jvk]], [[3muk]], [[3mul]], [[5nnd]], [[5nnc]] – mBRD4 bromodomain 1 + histone H3.3 peptide<br /> | |||
*Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex | *Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex | ||
**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]] – hBRD4 bromodomain 2 + inhibitor<br /> | **[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]], [[6duv]], [[6i80]], [[6i81]], [[6viz]] – hBRD4 bromodomain 2 + inhibitor<br /> | ||
**[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br /> | **[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br /> | ||
**[[4kv4]] – hBRD4 bromodomain 2 + Rel peptide<br /> | **[[4kv4]] – hBRD4 bromodomain 2 + Rel peptide<br /> | ||
**[[2mjv]] – hBRD4 bromodomain 2 + Twist peptide<br /> | **[[2mjv]] – hBRD4 bromodomain 2 + Twist peptide<br /> | ||
**[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br /> | **[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br /> | ||
**[[5t35]] – hBRD4 bromodomain 2 + | **[[5t35]], [[6sis]] – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide<br /> | ||
*Bromodomain-containing protein 7 | *Bromodomain-containing protein 7 | ||
**[[5mq1]] – hBRD7 bromodomain + inhibitor<br /> | **[[6ppa]] – hBRD7 bromodomain <br /> | ||
**[[5mq1]], [[6v0q]], [[6v16]], [[6v17]], [[6v1e]], [[6v1f]], [[6v1h]] – hBRD7 bromodomain + inhibitor<br /> | |||
*Bromodomain-containing protein 9 | *Bromodomain-containing protein 9 | ||
**[[3hme]] – hBRD9 bromodomain <br /> | **[[3hme]], [[6uzf]] – hBRD9 bromodomain <br /> | ||
**[[5ji8]] – hBRD9 JUS-SPRY domain <br /> | **[[5ji8]] – hBRD9 JUS-SPRY domain <br /> | ||
**[[5ign]] – hBRD9 bromodomain + L999 <br /> | **[[5ign]] – hBRD9 bromodomain + L999 <br /> | ||
**[[5igm]] – hBRD9 bromodomain + bromosporine <br /> | **[[5igm]] – hBRD9 bromodomain + bromosporine <br /> | ||
**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]] – hBRD9 bromodomain + inhibitor<br /> | **[[6v0x]] – hBRD9 bromodomain + sunitinib <br /> | ||
**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]], [[6v0s]], [[6v14]], [[6v1b]] – hBRD9 bromodomain + inhibitor<br /> | |||
**[[4yy4]] – hBRD9 bromodomain + DMSO<br /> | **[[4yy4]] – hBRD9 bromodomain + DMSO<br /> | ||
**[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br /> | **[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br /> | ||