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'''CYTOKYNE-BINDING REGION OF GP130''' | '''CYTOKYNE-BINDING REGION OF GP130''' | ||
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[[Category: Jones, E Y.]] | [[Category: Jones, E Y.]] | ||
[[Category: Staunton, D.]] | [[Category: Staunton, D.]] | ||
[[Category: | [[Category: Cytokine receptor]] | ||
[[Category: | [[Category: Glycoprotein 130]] | ||
[[Category: | [[Category: Gp130]] | ||
[[Category: | [[Category: Interleukine 6 receptor beta subunit]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:50:54 2008'' | |||
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Revision as of 11:50, 2 May 2008
CYTOKYNE-BINDING REGION OF GP130
OverviewOverview
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
About this StructureAbout this Structure
1BQU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088 Page seeded by OCA on Fri May 2 11:50:54 2008