2ux2: Difference between revisions
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==High resolution structure of human CD59== | ==High resolution structure of human CD59== | ||
<StructureSection load='2ux2' size='340' side='right' caption='[[2ux2]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2ux2' size='340' side='right'caption='[[2ux2]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ux2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UX2 OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[2ux2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UX2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UX2 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cdq|1cdq]], [[1cdr|1cdr]], [[1cds|1cds]], [[1erg|1erg]], [[1erh|1erh]], [[2j8b|2j8b]], [[2uwr|2uwr]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cdq|1cdq]], [[1cdr|1cdr]], [[1cds|1cds]], [[1erg|1erg]], [[1erh|1erh]], [[2j8b|2j8b]], [[2uwr|2uwr]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ux2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ux2 OCA], [http://pdbe.org/2ux2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ux2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ux2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ux2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Johnson, S]] | [[Category: Johnson, S]] | ||
[[Category: Lea, S M]] | [[Category: Lea, S M]] | ||
Revision as of 14:13, 17 June 2020
High resolution structure of human CD59High resolution structure of human CD59
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedCD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC). Crystals of bacterially expressed and nonglycosylated recombinant soluble human CD59 have been obtained from three crystallization conditions, each of which gave rise to a distinct crystal form. Each crystal form led to a crystal structure at high resolution (1.15, 1.35 and 1.8 A). In one of these structures the electron-density map shows an as yet unidentified small molecule in the predicted C8/C9-binding site. The presence/absence of this ligand is linked to alternate conformations of the amino acids implicated in C8/C9 binding. High-resolution structures of bacterially expressed soluble human CD59.,Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):648-52. Epub 2007 Jul 28. PMID:17671359[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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