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==Phenylalanine hydroxylase from dictyostelium - BH2 complex==
==Phenylalanine hydroxylase from dictyostelium - BH2 complex==
<StructureSection load='5jk5' size='340' side='right' caption='[[5jk5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='5jk5' size='340' side='right'caption='[[5jk5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jk5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JK5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JK5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JK5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jk6|5jk6]], [[5jk8|5jk8]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jk6|5jk6]], [[5jk8|5jk8]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jk5 OCA], [http://pdbe.org/5jk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jk5 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pah, DDB_G0278781 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jk5 OCA], [http://pdbe.org/5jk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jk5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PH4H_DICDI PH4H_DICDI]] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.<ref>PMID:18835579</ref>   
[[http://www.uniprot.org/uniprot/PH4H_DICDI PH4H_DICDI]] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.<ref>PMID:18835579</ref>   
==See Also==
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dicdi]]
[[Category: Large Structures]]
[[Category: Lee, K H]]
[[Category: Lee, K H]]
[[Category: Zhuang, N]]
[[Category: Zhuang, N]]

Revision as of 10:53, 10 June 2020

Phenylalanine hydroxylase from dictyostelium - BH2 complexPhenylalanine hydroxylase from dictyostelium - BH2 complex

Structural highlights

5jk5 is a 2 chain structure with sequence from Dicdi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:pah, DDB_G0278781 (DICDI)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PH4H_DICDI] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.[1]

See Also

References

  1. ↑ Siltberg-Liberles J, Steen IH, Svebak RM, Martinez A. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 2008 Dec 31;427(1-2):86-92. doi: 10.1016/j.gene.2008.09.005. Epub 2008 Sep , 16. PMID:18835579 doi:http://dx.doi.org/10.1016/j.gene.2008.09.005

5jk5, resolution 2.07Å

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