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<Structure load=' | <Structure load='6M03' size='350' side='right' caption='Main Protease' scene=''> | ||
Anything in this section will appear adjacent to the 3D structure and will be scrollable. | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
Revision as of 03:55, 5 June 2020
SARS-CoV-2 main protease (Mpro)SARS-CoV-2 main protease (Mpro)
The Mpro protease (also known as 3CLpro), is a viral non structural protein from the virus SARS-CoV-2 (1), responsible for a major outbreak of the disease called COVID-19, declared pandemic by WHO in 11 march 2020 (2). It has an important role in virus replication, as it’s responsible for cleavage of the polyproteins of the virus, alongside with papain-like protease(s) (3).
Your Heading Here (maybe something like 'Structure')Your Heading Here (maybe something like 'Structure')
<Structure load='6M03' size='350' side='right' caption='Main Protease' scene=>
Anything in this section will appear adjacent to the 3D structure and will be scrollable.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
FunctionFunction
StructureStructure
An attractive drug targetAn attractive drug target
Structural comparison with SARS-CoV MproStructural comparison with SARS-CoV Mpro
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
ReferencesReferences
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644