SARS-CoV-2 enzyme NendoU: Difference between revisions
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The exact functional relevance of Nsp15 is currently unknown. Nsp15-deficient corona viruses remain viable and replicating <ref name="structure">PMID:32304108</ref>. However, conflicting studies have been published on Nsp15’s role in interfering with the innate immune response <ref>PMID:28484023</ref>,<ref>PMID:31351410</ref> and it has been suggested that Nsp15 degrades viral RNA as a method to hide it from host defences <ref name="structure" />. | The exact functional relevance of Nsp15 is currently unknown. Nsp15-deficient corona viruses remain viable and replicating <ref name="structure">PMID:32304108</ref>. However, conflicting studies have been published on Nsp15’s role in interfering with the innate immune response <ref>PMID:28484023</ref>,<ref>PMID:31351410</ref> and it has been suggested that Nsp15 degrades viral RNA as a method to hide it from host defences <ref name="structure" />. | ||
== Disease == | == Disease == | ||
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SARS-CoV-2 Nsp15 from SARS-CoV-2 resembles previously observed endonucleases from SARS-CoV (0.52 Å RMSD, PDBID: 2H85) and MERS-CoV (1.16 Å RMSD, PDBID: 5YVD) <ref name="structure" />. | SARS-CoV-2 Nsp15 from SARS-CoV-2 resembles previously observed endonucleases from SARS-CoV (0.52 Å RMSD, PDBID: 2H85) and MERS-CoV (1.16 Å RMSD, PDBID: 5YVD) <ref name="structure" />. | ||
== See also == | == See also == | ||