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==A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 95.2 us after photoexcitation==
==A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 95.2 us after photoexcitation==
<StructureSection load='5h2n' size='340' side='right' caption='[[5h2n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5h2n' size='340' side='right'caption='[[5h2n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5h2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum_nrc-1 Halobacterium salinarum nrc-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H2N FirstGlance]. <br>
<table><tr><td colspan='2'>[[5h2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum_nrc-1 Halobacterium salinarum nrc-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H2N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H2N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C14:TETRADECANE'>C14</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=L2P:2,3-DI-PHYTANYL-GLYCEROL'>L2P</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=TRD:TRIDECANE'>TRD</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C14:TETRADECANE'>C14</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=L2P:2,3-DI-PHYTANYL-GLYCEROL'>L2P</scene>, <scene name='pdbligand=MYS:PENTADECANE'>MYS</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=TRD:TRIDECANE'>TRD</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b6v|5b6v]], [[5b6w|5b6w]], [[5b6x|5b6x]], [[5b6y|5b6y]], [[5b6z|5b6z]], [[5h2h|5h2h]], [[5h2i|5h2i]], [[5h2j|5h2j]], [[5h2k|5h2k]], [[5h2l|5h2l]], [[5h2m|5h2m]], [[5h2o|5h2o]], [[5h2p|5h2p]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b6v|5b6v]], [[5b6w|5b6w]], [[5b6x|5b6x]], [[5b6y|5b6y]], [[5b6z|5b6z]], [[5h2h|5h2h]], [[5h2i|5h2i]], [[5h2j|5h2j]], [[5h2k|5h2k]], [[5h2l|5h2l]], [[5h2m|5h2m]], [[5h2o|5h2o]], [[5h2p|5h2p]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h2n OCA], [http://pdbe.org/5h2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h2n RCSB], [http://www.ebi.ac.uk/pdbsum/5h2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h2n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h2n OCA], [http://pdbe.org/5h2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h2n RCSB], [http://www.ebi.ac.uk/pdbsum/5h2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 5h2n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h2n" style="background-color:#fffaf0;"></div>
==See Also==
*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Halobacterium salinarum nrc-1]]
[[Category: Halobacterium salinarum nrc-1]]
[[Category: Large Structures]]
[[Category: Arima, T]]
[[Category: Arima, T]]
[[Category: Iwata, S]]
[[Category: Iwata, S]]

Revision as of 09:50, 20 May 2020

A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 95.2 us after photoexcitationA three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 95.2 us after photoexcitation

Structural highlights

5h2n is a 1 chain structure with sequence from Halobacterium salinarum nrc-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BACR_HALSA] Light-driven proton pump.

Publication Abstract from PubMed

Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron laser to visualize conformational changes in bR from nanoseconds to milliseconds following photoactivation. An initially twisted retinal chromophore displaces a conserved tryptophan residue of transmembrane helix F on the cytoplasmic side of the protein while dislodging a key water molecule on the extracellular side. The resulting cascade of structural changes throughout the protein shows how motions are choreographed as bR transports protons uphill against a transmembrane concentration gradient.

A three-dimensional movie of structural changes in bacteriorhodopsin.,Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Bath P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S Science. 2016 Dec 23;354(6319):1552-1557. doi: 10.1126/science.aah3497. PMID:28008064[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Bath P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S. A three-dimensional movie of structural changes in bacteriorhodopsin. Science. 2016 Dec 23;354(6319):1552-1557. doi: 10.1126/science.aah3497. PMID:28008064 doi:http://dx.doi.org/10.1126/science.aah3497

5h2n, resolution 2.10Å

Drag the structure with the mouse to rotate

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