CD81: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
+CD81 is a cell-surface protein involved in a variety of biological responses like adhesion, morphology, activation, proliferation adn differentiation of of B- and T-cells<ref>PMID:9597125</ref>.  CD81 belongs to the tetraspanin family - protein containing 4 transmembrane domains - which form microdomains in the cell surface with a variety of partner proteins.
 == Disease ==
 == Relevance ==
+CD81 is widely expressed on the majority of tumor cells.  Antibodies that target CD81 are a novel treatment against B-cell lymphoma<ref>PMID:31123084</ref>.  CD81-defficient mice are impaired in their ability to suppress the anti-tumor immune response.
 == Structural highlights ==
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 ==3D structures of CD81==
-[[1g8q]] - hCD81 extracellular domain 113-202 - human<br />
+[[5tcx]] - hCD81 (mutant) - human<br />
+[[1g8q]], [[1iv5]], [[5m3t]], [[5m3d]], [[5m4r]], [[5m33]], [[5m2c]], [[3x0e]], [[3x0f]] - hCD81 extracellular domain 113-202<br />
+[[6ejm]], [[6ek2]], [[6ejg]], [[5dfw]] - hCD81 extracellular domain + Scfv<br />
+[[5dfv]] - hCD81 extracellular domain + antibody<br />
 [[3k0g]] - CD81 extracellular domain - green monkey<br />
+[[6u9s]] - CD81 extracellular domain + antibody - mouse<br />
 == References ==
 <references/>