Sandbox 30008: Difference between revisions
New page: <StructureSection load='4a5a' size='340' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB code 4a5a)' scene=''> == Function == '''Nucleoside trip... |
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< | <SX viewer='molstar' load='4a5a' size='323' side='right' caption='NTPase 2 tetramer complex with AMPPNP and Mg++ ion (green) (PDB code [[4a5a]]).' scene=''> | ||
== Function == | == Function == | ||
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The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>. | The 3D structure of the complex between NTPase 2 and the ATP analog AMPPNP shows the NTPase structure composed of two domains. Domain I contains the N-terminal and C-terminal and domain II the core residues. The structure contains 7 Cys-Cys bonds one of which located between domain I and II and reaching the diametrically positioned monomer was found by mutational analysis to be responsible for activation. The ATP analog - AMPPNP - is located in a cleft and forms interactions with domain I and domain II<ref>PMID:22130673</ref>. | ||
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==3D structures of nucleoside triphosphatase== | ==3D structures of nucleoside triphosphatase== | ||